2-(((3R,6R)-1-(2-(2H-1,2,3-triazol-2-yl)benzoyl)-6-methylpiperidin-3-yl)(methyl)amino)isonicotinonitrile

Base Information

Chemical Name:2-(((3R,6R)-1-(2-(2H-1,2,3-triazol-2-yl)benzoyl)-6-methylpiperidin-3-yl)(methyl)amino)isonicotinonitrile
CAS No.:1612786-21-6
Molecular Formula:C₂₂H₂₃N₇O
Molecular Weight:401.471
Hs Code.:

Synonyms:2-(((3R,6R)-1-(2-(2H-1,2,3-triazol-2-yl)benzoyl)-6-methylpiperidin-3-yl)(methyl)amino)isonicotinonitrile

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Chemical Property of 2-(((3R,6R)-1-(2-(2H-1,2,3-triazol-2-yl)benzoyl)-6-methylpiperidin-3-yl)(methyl)amino)isonicotinonitrile

Chemical Property:

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Technology Process of 2-(((3R,6R)-1-(2-(2H-1,2,3-triazol-2-yl)benzoyl)-6-methylpiperidin-3-yl)(methyl)amino)isonicotinonitrile

There total 9 articles about 2-(((3R,6R)-1-(2-(2H-1,2,3-triazol-2-yl)benzoyl)-6-methylpiperidin-3-yl)(methyl)amino)isonicotinonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1612786-14-7
2-(((3R,6R)-1-(2-(2H-1,2,3-triazol-2-yl)benzoyl)-6-methylpiperidin-3-yl)amino)isonicotinonitrile

: 74-88-4
methyl iodide

: 1612786-21-6
2-(((3R,6R)-1-(2-(2H-1,2,3-triazol-2-yl)benzoyl)-6-methylpiperidin-3-yl)(methyl)amino)isonicotinonitrile

Guidance literature:: 2-(((3R,6R)-1-(2-(2H-1,2,3-triazol-2-yl)benzoyl)-6-methylpiperidin-3-yl)amino)isonicotinonitrile; With sodium hydride; In N,N-dimethyl-formamide; at 20 ℃;

methyl iodide; In N,N-dimethyl-formamide;

Reference yield:

: 1207853-22-2
(2R,5R)-benzyl-5-((tert-butoxycarbonyl)amino-2-methyl)piperidine-1-carboxylate

: 1612786-21-6
2-(((3R,6R)-1-(2-(2H-1,2,3-triazol-2-yl)benzoyl)-6-methylpiperidin-3-yl)(methyl)amino)isonicotinonitrile

Guidance literature:: Multi-step reaction with 5 steps

1: palladium 10% on activated carbon; hydrogen / ethanol; methanol / 20 °C

2: 1-hydroxy-7-aza-benzotriazole; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 50 °C

3: hydrogenchloride / ethyl acetate / 2 h

4: caesium carbonate / dimethyl sulfoxide / 48 h / 50 °C

5: sodium hydride / N,N-dimethyl-formamide / 20 °C

With hydrogenchloride; 1-hydroxy-7-aza-benzotriazole; palladium 10% on activated carbon; hydrogen; sodium hydride; caesium carbonate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; In methanol; ethanol; dimethyl sulfoxide; ethyl acetate; N,N-dimethyl-formamide;

Reference yield:

: 1222491-53-3,1227916-38-2
tert-butyl ((3R,6R)-6-methylpiperidin-3-yl)carbamate

: 1612786-21-6
2-(((3R,6R)-1-(2-(2H-1,2,3-triazol-2-yl)benzoyl)-6-methylpiperidin-3-yl)(methyl)amino)isonicotinonitrile

Guidance literature:: Multi-step reaction with 4 steps

1: 1-hydroxy-7-aza-benzotriazole; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 50 °C

2: hydrogenchloride / ethyl acetate / 2 h

3: caesium carbonate / dimethyl sulfoxide / 48 h / 50 °C

4: sodium hydride / N,N-dimethyl-formamide / 20 °C

With hydrogenchloride; 1-hydroxy-7-aza-benzotriazole; sodium hydride; caesium carbonate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; In dimethyl sulfoxide; ethyl acetate; N,N-dimethyl-formamide;