2-[4-(HYDROXYMETHYL)-2-NITROPHENOXY]ACETIC ACID METHYL ESTER

Base Information

• Chemical Name: 2-[4-(HYDROXYMETHYL)-2-NITROPHENOXY]ACETIC ACID METHYL ESTER
• CAS No.: 308815-81-8
• Molecular Formula: C10H11 N O6
• Molecular Weight: 241.2
• Hs Code.: 2918990090
• Mol file: 308815-81-8.mol

Synonyms:Aceticacid, [4-(hydroxymethyl)-2-nitrophenoxy]-, methyl ester (9CI)

Chemical Property of 2-[4-(HYDROXYMETHYL)-2-NITROPHENOXY]ACETIC ACID METHYL ESTER

Chemical Property:

• Vapor Pressure: 0mmHg at 25°C
• Melting Point: 77.0 to 81.0 °C
• Refractive Index: 1.562
• Boiling Point: 423.389°C at 760 mmHg
• Flash Point: 209.859°C
• PSA: 101.58000
• Density: 1.374g/cm³
• LogP: 1.16210
• Solubility.: almost transparency in Methanol

Purity/Quality:

97% ^*data from raw suppliers

Methyl 2-[4-(Hydroxymethyl)-2-nitrophenoxy]acetate >98.0%(GC) ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-[4-(HYDROXYMETHYL)-2-NITROPHENOXY]ACETIC ACID METHYL ESTER

There total 2 articles about 2-[4-(HYDROXYMETHYL)-2-NITROPHENOXY]ACETIC ACID METHYL ESTER which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

4-methoxylcarbonylmethoxy-3-nitro-benzaldehyde (476313-39-0) → methyl 2-[4-(hydroxymethyl)-2-nitrophenoxy]acetate (308815-81-8)

Guidance literature:

With sodium tetrahydroborate; In ethanol;

Reference yield:

4-hydroxy-3-nitrobenzaldehyde (3011-34-5) → methyl 2-[4-(hydroxymethyl)-2-nitrophenoxy]acetate (308815-81-8)

Guidance literature:

Multi-step reaction with 2 steps

1: K₂CO₃ / acetonitrile

2: NaBH₄ / ethanol

With sodium tetrahydroborate; potassium carbonate; In ethanol; acetonitrile; 1: Alkylation / 2: Reduction;

Reference yield: 96.0%

tert-butyldimethylsilyl chloride (18162-48-6) + methyl 2-[4-(hydroxymethyl)-2-nitrophenoxy]acetate (308815-81-8) → methyl 2-(4-(((tert-butyldimethylsilyl)oxy)methyl)-2-nitrophenoxy)acetate

Guidance literature:

With 1H-imidazole; In dichloromethane; at 20 ℃; for 2h; Sealed tube; Inert atmosphere; Darkness;

DOI:10.1002/anie.201602941

upstream raw materials:

4-methoxylcarbonylmethoxy-3-nitro-benzaldehyde

4-hydroxy-3-nitrobenzaldehyde

Downstream raw materials:

[2-Nitro-4-(2,2,2-trichloro-acetimidoyloxymethyl)-phenoxy]-acetic acid methyl ester

[4-(tert-butyl-dimethyl-silanyloxymethyl)-2-nitro-phenoxy]-acetic acid