2-(4-((5-fluoro-4-((3-(methylamino)phenyl)amino)pyrimidin-2-yl)amino)phenoxy)ethanol

Base Information

Chemical Name:2-(4-((5-fluoro-4-((3-(methylamino)phenyl)amino)pyrimidin-2-yl)amino)phenoxy)ethanol
CAS No.:1616380-99-4
Molecular Formula:C₁₉H₂₀FN₅O₂
Molecular Weight:369.399
Hs Code.:

Synonyms:2-(4-((5-fluoro-4-((3-(methylamino)phenyl)amino)pyrimidin-2-yl)amino)phenoxy)ethanol

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Chemical Property of 2-(4-((5-fluoro-4-((3-(methylamino)phenyl)amino)pyrimidin-2-yl)amino)phenoxy)ethanol

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Technology Process of 2-(4-((5-fluoro-4-((3-(methylamino)phenyl)amino)pyrimidin-2-yl)amino)phenoxy)ethanol

There total 10 articles about 2-(4-((5-fluoro-4-((3-(methylamino)phenyl)amino)pyrimidin-2-yl)amino)phenoxy)ethanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1616380-98-3
tert-butyl (3-((5-fluoro-2-((4-(2-((2-methoxyethoxy)methoxy)ethoxy)phenyl)amino)pyrimidin-4-yl)amino)phenyl)(methyl)carbamate

: 1616380-99-4
2-(4-((5-fluoro-4-((3-(methylamino)phenyl)amino)pyrimidin-2-yl)amino)phenoxy)ethanol

Guidance literature:: With trifluoroacetic acid; at 0 ℃; for 8h;

Reference yield:

: 1616380-95-0
1-(2-((2-methoxyethoxy)methoxy)ethoxy)-4-nitrobenzene

: 1616380-99-4
2-(4-((5-fluoro-4-((3-(methylamino)phenyl)amino)pyrimidin-2-yl)amino)phenoxy)ethanol

Guidance literature:: Multi-step reaction with 3 steps

1.1: palladium on activated charcoal; hydrogen / methanol / 2 h / 20 °C / Inert atmosphere

2.1: 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; caesium carbonate / 1,4-dioxane / 0.5 h / Inert atmosphere

2.2: 4 h / 80 °C / Inert atmosphere

3.1: trifluoroacetic acid / 8 h / 0 °C

With palladium on activated charcoal; hydrogen; caesium carbonate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; trifluoroacetic acid; In 1,4-dioxane; methanol; 2.1: |Buchwald-Hartwig Coupling / 2.2: |Buchwald-Hartwig Coupling;

Reference yield:

: 1616380-96-1
4-(2-((2-methoxyethoxy)methoxy)ethoxy)aniline

: 1616380-99-4
2-(4-((5-fluoro-4-((3-(methylamino)phenyl)amino)pyrimidin-2-yl)amino)phenoxy)ethanol

Guidance literature:: Multi-step reaction with 2 steps

1.1: 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; caesium carbonate / 1,4-dioxane / 0.5 h / Inert atmosphere

1.2: 4 h / 80 °C / Inert atmosphere

2.1: trifluoroacetic acid / 8 h / 0 °C

With caesium carbonate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; trifluoroacetic acid; In 1,4-dioxane; 1.1: |Buchwald-Hartwig Coupling / 1.2: |Buchwald-Hartwig Coupling;