Technology Process of tert-butyl (3-((2-chloro-5-fluoropyrimidin-4-yl)amino)phenyl)(methyl)carbamate
There total 5 articles about tert-butyl (3-((2-chloro-5-fluoropyrimidin-4-yl)amino)phenyl)(methyl)carbamate which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
N-ethyl-N,N-diisopropylamine;
In
butan-1-ol;
at 120 ℃;
for 3h;
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: sodium hydride / N,N-dimethyl-formamide / 1 h / 20 °C / Inert atmosphere
1.2: 2 h / 0 - 20 °C / Inert atmosphere
2.1: palladium on activated charcoal; hydrogen / methanol / 3 h / 20 °C / 3750.38 Torr / Autoclave
3.1: N-ethyl-N,N-diisopropylamine / butan-1-ol / 3 h / 120 °C
With
palladium on activated charcoal; hydrogen; sodium hydride; N-ethyl-N,N-diisopropylamine;
In
methanol; N,N-dimethyl-formamide; butan-1-ol;
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: dmap / tetrahydrofuran / 5 h / 0 - 20 °C
2.1: sodium hydride / N,N-dimethyl-formamide / 1 h / 20 °C / Inert atmosphere
2.2: 2 h / 0 - 20 °C / Inert atmosphere
3.1: palladium on activated charcoal; hydrogen / methanol / 3 h / 20 °C / 3750.38 Torr / Autoclave
4.1: N-ethyl-N,N-diisopropylamine / butan-1-ol / 3 h / 120 °C
With
dmap; palladium on activated charcoal; hydrogen; sodium hydride; N-ethyl-N,N-diisopropylamine;
In
tetrahydrofuran; methanol; N,N-dimethyl-formamide; butan-1-ol;