N-(3-((5-fluoro-2-((4-(2-hydroxyethoxy)phenyl)amino)pyrimidin-4-yl)amino)phenyl)-N-methylacrylamide

Base Information

Chemical Name:N-(3-((5-fluoro-2-((4-(2-hydroxyethoxy)phenyl)amino)pyrimidin-4-yl)amino)phenyl)-N-methylacrylamide
CAS No.:1616380-47-2
Molecular Formula:C₂₂H₂₂FN₅O₃
Molecular Weight:423.447
Hs Code.:

Synonyms:N-(3-((5-fluoro-2-((4-(2-hydroxyethoxy)phenyl)amino)pyrimidin-4-yl)amino)phenyl)-N-methylacrylamide

Suppliers and Price of N-(3-((5-fluoro-2-((4-(2-hydroxyethoxy)phenyl)amino)pyrimidin-4-yl)amino)phenyl)-N-methylacrylamide

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of N-(3-((5-fluoro-2-((4-(2-hydroxyethoxy)phenyl)amino)pyrimidin-4-yl)amino)phenyl)-N-methylacrylamide

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of N-(3-((5-fluoro-2-((4-(2-hydroxyethoxy)phenyl)amino)pyrimidin-4-yl)amino)phenyl)-N-methylacrylamide

There total 11 articles about N-(3-((5-fluoro-2-((4-(2-hydroxyethoxy)phenyl)amino)pyrimidin-4-yl)amino)phenyl)-N-methylacrylamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1616380-99-4
2-(4-((5-fluoro-4-((3-(methylamino)phenyl)amino)pyrimidin-2-yl)amino)phenoxy)ethanol

: 625-36-5
2-chloropropionyl chloride

: 1616380-47-2
N-(3-((5-fluoro-2-((4-(2-hydroxyethoxy)phenyl)amino)pyrimidin-4-yl)amino)phenyl)-N-methylacrylamide

Guidance literature:: With triethylamine; In dichloromethane; at -50 ℃; for 0.25h;

Reference yield:

: 1616380-98-3
tert-butyl (3-((5-fluoro-2-((4-(2-((2-methoxyethoxy)methoxy)ethoxy)phenyl)amino)pyrimidin-4-yl)amino)phenyl)(methyl)carbamate

: 1616380-47-2
N-(3-((5-fluoro-2-((4-(2-hydroxyethoxy)phenyl)amino)pyrimidin-4-yl)amino)phenyl)-N-methylacrylamide

Guidance literature:: Multi-step reaction with 2 steps

1: trifluoroacetic acid / 8 h / 0 °C

2: triethylamine / dichloromethane / 0.25 h / -50 °C

With triethylamine; trifluoroacetic acid; In dichloromethane;

Reference yield:

: 1616380-95-0
1-(2-((2-methoxyethoxy)methoxy)ethoxy)-4-nitrobenzene

: 1616380-47-2
N-(3-((5-fluoro-2-((4-(2-hydroxyethoxy)phenyl)amino)pyrimidin-4-yl)amino)phenyl)-N-methylacrylamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: palladium on activated charcoal; hydrogen / methanol / 2 h / 20 °C / Inert atmosphere

2.1: 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; caesium carbonate / 1,4-dioxane / 0.5 h / Inert atmosphere

2.2: 4 h / 80 °C / Inert atmosphere

3.1: trifluoroacetic acid / 8 h / 0 °C

4.1: triethylamine / dichloromethane / 0.25 h / -50 °C

With palladium on activated charcoal; hydrogen; caesium carbonate; triethylamine; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; trifluoroacetic acid; In 1,4-dioxane; methanol; dichloromethane; 2.1: |Buchwald-Hartwig Coupling / 2.2: |Buchwald-Hartwig Coupling;