tert-butyl (3-((5-fluoro-2-((4-(2-((2-methoxyethoxy)methoxy)ethoxy)phenyl)amino)pyrimidin-4-yl)amino)phenyl)(methyl)carbamate

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Chemical Name:tert-butyl (3-((5-fluoro-2-((4-(2-((2-methoxyethoxy)methoxy)ethoxy)phenyl)amino)pyrimidin-4-yl)amino)phenyl)(methyl)carbamate
CAS No.:1616380-98-3
Molecular Formula:C₂₈H₃₆FN₅O₆
Molecular Weight:557.622
Hs Code.:

Synonyms:tert-butyl (3-((5-fluoro-2-((4-(2-((2-methoxyethoxy)methoxy)ethoxy)phenyl)amino)pyrimidin-4-yl)amino)phenyl)(methyl)carbamate

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Chemical Property of tert-butyl (3-((5-fluoro-2-((4-(2-((2-methoxyethoxy)methoxy)ethoxy)phenyl)amino)pyrimidin-4-yl)amino)phenyl)(methyl)carbamate

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Technology Process of tert-butyl (3-((5-fluoro-2-((4-(2-((2-methoxyethoxy)methoxy)ethoxy)phenyl)amino)pyrimidin-4-yl)amino)phenyl)(methyl)carbamate

There total 9 articles about tert-butyl (3-((5-fluoro-2-((4-(2-((2-methoxyethoxy)methoxy)ethoxy)phenyl)amino)pyrimidin-4-yl)amino)phenyl)(methyl)carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1616380-96-1
4-(2-((2-methoxyethoxy)methoxy)ethoxy)aniline

: 1616380-97-2
tert-butyl (3-((2-chloro-5-fluoropyrimidin-4-yl)amino)phenyl)(methyl)carbamate

: 1616380-98-3
tert-butyl (3-((5-fluoro-2-((4-(2-((2-methoxyethoxy)methoxy)ethoxy)phenyl)amino)pyrimidin-4-yl)amino)phenyl)(methyl)carbamate

Guidance literature:: 4-(2-((2-methoxyethoxy)methoxy)ethoxy)aniline; tert-butyl (3-((2-chloro-5-fluoropyrimidin-4-yl)amino)phenyl)(methyl)carbamate; With caesium carbonate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; In 1,4-dioxane; for 0.5h; Inert atmosphere;

With palladium diacetate; In 1,4-dioxane; at 80 ℃; for 4h; Inert atmosphere;

Reference yield:

: 1616380-95-0
1-(2-((2-methoxyethoxy)methoxy)ethoxy)-4-nitrobenzene

: 1616380-98-3
tert-butyl (3-((5-fluoro-2-((4-(2-((2-methoxyethoxy)methoxy)ethoxy)phenyl)amino)pyrimidin-4-yl)amino)phenyl)(methyl)carbamate

Guidance literature:: Multi-step reaction with 2 steps

1.1: palladium on activated charcoal; hydrogen / methanol / 2 h / 20 °C / Inert atmosphere

2.1: 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; caesium carbonate / 1,4-dioxane / 0.5 h / Inert atmosphere

2.2: 4 h / 80 °C / Inert atmosphere

With palladium on activated charcoal; hydrogen; caesium carbonate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; In 1,4-dioxane; methanol; 2.1: |Buchwald-Hartwig Coupling / 2.2: |Buchwald-Hartwig Coupling;

Reference yield:

: 350-46-9,178603-76-4
4-Fluoronitrobenzene

: 1616380-98-3
tert-butyl (3-((5-fluoro-2-((4-(2-((2-methoxyethoxy)methoxy)ethoxy)phenyl)amino)pyrimidin-4-yl)amino)phenyl)(methyl)carbamate

Guidance literature:: Multi-step reaction with 4 steps

1.1: caesium carbonate / 0.5 h / 80 °C

2.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 16 h / 0 - 20 °C / Inert atmosphere

3.1: palladium on activated charcoal; hydrogen / methanol / 2 h / 20 °C / Inert atmosphere

4.1: 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; caesium carbonate / 1,4-dioxane / 0.5 h / Inert atmosphere

4.2: 4 h / 80 °C / Inert atmosphere

With palladium on activated charcoal; hydrogen; caesium carbonate; N-ethyl-N,N-diisopropylamine; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; In 1,4-dioxane; methanol; dichloromethane; 4.1: |Buchwald-Hartwig Coupling / 4.2: |Buchwald-Hartwig Coupling;