(S)-benzyl 2-(tert-butoxycarbonylamino)-4-(methoxy(methyl)amino)-4-oxobutanoate

Base Information

• Chemical Name: (S)-benzyl 2-(tert-butoxycarbonylamino)-4-(methoxy(methyl)amino)-4-oxobutanoate
• CAS No.: 1079307-01-9
• Molecular Formula: C₁₈H₂₆N₂O₆
• Molecular Weight: 366.414
• Mol file: 1079307-01-9.mol

Synonyms:(S)-benzyl 2-(tert-butoxycarbonylamino)-4-(methoxy(methyl)amino)-4-oxobutanoate

Chemical Property of (S)-benzyl 2-(tert-butoxycarbonylamino)-4-(methoxy(methyl)amino)-4-oxobutanoate

Chemical Property:

Purity/Quality:

98% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (S)-benzyl 2-(tert-butoxycarbonylamino)-4-(methoxy(methyl)amino)-4-oxobutanoate

There total 4 articles about (S)-benzyl 2-(tert-butoxycarbonylamino)-4-(methoxy(methyl)amino)-4-oxobutanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

2-tert-butoxycarbonylamino-succinic acid 1-benzyl ester (30925-18-9) + N,O-dimethylhydroxylamine*hydrochloride (6638-79-5) → (S)-benzyl 2-(tert-butoxycarbonylamino)-4-(methoxy(methyl)amino)-4-oxobutanoate (1079307-01-9)

Guidance literature:

With 2,4,6-tripropyl-1,3,5,2,4,6-trioxatriphosphinane-2,4,6-trioxide; N-ethyl-N,N-diisopropylamine; In dichloromethane; ethyl acetate; at 0 ℃; for 1h; Inert atmosphere;

DOI:10.1021/acs.jmedchem.1c00296

Reference yield:

C16H20ClNO5 + N,O-dimethylhydroxylamine*hydrochloride (6638-79-5) → (S)-benzyl 2-(tert-butoxycarbonylamino)-4-(methoxy(methyl)amino)-4-oxobutanoate (1079307-01-9)

Guidance literature:

In dichloromethane; at 20 ℃; Inert atmosphere;

DOI:10.1080/00397911.2018.1531295

Reference yield:

N,O-dimethylhydroxylamine*hydrochloride (6638-79-5) + (S)-2-tert-Butoxycarbonylamino-4-isobutoxycarbonyloxy-4-oxo-butyric acid benzyl ester → (S)-benzyl 2-(tert-butoxycarbonylamino)-4-(methoxy(methyl)amino)-4-oxobutanoate (1079307-01-9)

Guidance literature:

N,O-dimethylhydroxylamine*hydrochloride; With triethylamine; In N,N-dimethyl-formamide;

(S)-2-tert-Butoxycarbonylamino-4-isobutoxycarbonyloxy-4-oxo-butyric acid benzyl ester; In tetrahydrofuran; N,N-dimethyl-formamide; at 0 - 20 ℃;

DOI:10.1021/jo801754k

upstream raw materials:

N,O-dimethylhydroxylamine*hydrochloride

2-tert-butoxycarbonylamino-succinic acid 1-benzyl ester

Downstream raw materials:

(S)-benzyl-4-oxo-2-<<(1,1-dimethylethoxy)carbonyl>amino>butanoate