(S)-2-((tert-butyldimethylsilyl)oxy)-3-(4-((tert-butyldimethylsilyl)oxy)phenyl)-N-methoxy-N-methylpropanamide

Base Information

Chemical Name:(S)-2-((tert-butyldimethylsilyl)oxy)-3-(4-((tert-butyldimethylsilyl)oxy)phenyl)-N-methoxy-N-methylpropanamide
CAS No.:1236191-25-5
Molecular Formula:C₂₃H₄₃NO₄Si₂
Molecular Weight:453.77
Hs Code.:

Synonyms:(S)-2-((tert-butyldimethylsilyl)oxy)-3-(4-((tert-butyldimethylsilyl)oxy)phenyl)-N-methoxy-N-methylpropanamide

Suppliers and Price of (S)-2-((tert-butyldimethylsilyl)oxy)-3-(4-((tert-butyldimethylsilyl)oxy)phenyl)-N-methoxy-N-methylpropanamide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (S)-2-((tert-butyldimethylsilyl)oxy)-3-(4-((tert-butyldimethylsilyl)oxy)phenyl)-N-methoxy-N-methylpropanamide

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

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Technology Process of (S)-2-((tert-butyldimethylsilyl)oxy)-3-(4-((tert-butyldimethylsilyl)oxy)phenyl)-N-methoxy-N-methylpropanamide

There total 6 articles about (S)-2-((tert-butyldimethylsilyl)oxy)-3-(4-((tert-butyldimethylsilyl)oxy)phenyl)-N-methoxy-N-methylpropanamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 915396-55-3
(S)-2-hydroxy-3-(4-hydroxyphenyl)-N-methoxy-N-methylpropanamide

: 18162-48-6
tert-butyldimethylsilyl chloride

: 1236191-25-5
(S)-2-((tert-butyldimethylsilyl)oxy)-3-(4-((tert-butyldimethylsilyl)oxy)phenyl)-N-methoxy-N-methylpropanamide

Guidance literature:: (S)-2-hydroxy-3-(4-hydroxyphenyl)-N-methoxy-N-methylpropanamide; With 1H-imidazole; In N,N-dimethyl-formamide; at 0 ℃; for 0.166667h;

tert-butyldimethylsilyl chloride; In N,N-dimethyl-formamide; at 20 ℃; for 18h;
DOI:10.1016/j.tetlet.2016.06.070

Reference yield: 81.0%

: (S)-3-(4-O-tert-butyldimethylsiloxyphenyl)-2-tert-butyldimethylsiloxypropionyl methyl ester

: 6638-79-5
N,O-dimethylhydroxylamine*hydrochloride

: 1236191-25-5
(S)-2-((tert-butyldimethylsilyl)oxy)-3-(4-((tert-butyldimethylsilyl)oxy)phenyl)-N-methoxy-N-methylpropanamide

Guidance literature:: With isopropylmagnesium chloride; In tetrahydrofuran; at -20 ℃; Inert atmosphere;
DOI:10.1021/ol1013526

Reference yield:

: 6272-45-3,227105-11-5
(E)-4-benzyloxycinnamic acid

: 1236191-25-5
(S)-2-((tert-butyldimethylsilyl)oxy)-3-(4-((tert-butyldimethylsilyl)oxy)phenyl)-N-methoxy-N-methylpropanamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 56 h / 20 °C

2.1: potassium carbonate; osmium(VIII) oxide; potassium hexacyanoferrate(III); 1,4-bis(9-O-dihydroquinidine)phthalazine / water; tert-butyl alcohol; tetrahydrofuran / 18 h / 0 - 20 °C

3.1: palladium 10% on activated carbon; hydrogen / methanol / 110 h / 20 °C / 3420.23 Torr

4.1: 1H-imidazole / N,N-dimethyl-formamide / 0.17 h / 0 °C

4.2: 18 h / 20 °C

With 1H-imidazole; osmium(VIII) oxide; palladium 10% on activated carbon; hydrogen; potassium carbonate; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; 1,4-bis(9-O-dihydroquinidine)phthalazine; N-ethyl-N,N-diisopropylamine; potassium hexacyanoferrate(III); In tetrahydrofuran; methanol; water; N,N-dimethyl-formamide; tert-butyl alcohol; 2.1: |Sharpless Dihydroxylation;
DOI:10.1016/j.tetlet.2016.06.070