(S)-3-(4-chlorophenyl)-glutaric acid monomethyl ester

Base Information

Chemical Name:(S)-3-(4-chlorophenyl)-glutaric acid monomethyl ester
CAS No.:865366-99-0
Molecular Formula:C₁₂H₁₃ClO₄
Molecular Weight:256.686
Hs Code.:

Synonyms:(S)-3-(4-chlorophenyl)-glutaric acid monomethyl ester

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Chemical Property of (S)-3-(4-chlorophenyl)-glutaric acid monomethyl ester

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Technology Process of (S)-3-(4-chlorophenyl)-glutaric acid monomethyl ester

There total 7 articles about (S)-3-(4-chlorophenyl)-glutaric acid monomethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 67-56-1
methanol

: 53911-68-5
3-(4-chlorophenyl)glutaric anhydride

: 137310-16-8
(R)-3-(4-chlorophenyl)-glutaric acid monomethyl ester

: 865366-99-0
(S)-3-(4-chlorophenyl)-glutaric acid monomethyl ester

Guidance literature:: With Novozym 435; In di-isopropyl ether; at 20 ℃; for 120h; Title compound not separated from byproducts;
DOI:10.1016/j.tetasy.2005.06.025

Reference yield:

: 1615-02-7,940-62-5
3-(4-chlorophenyl)prop-2-enoic acid

: 865366-99-0
(S)-3-(4-chlorophenyl)-glutaric acid monomethyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: 95 percent / Dowex H+ resin / Heating

2: 85 percent / MeONa / tetrahydrofuran / Heating

3: 79 percent / NaCl / dimethylsulfoxide; H₂O / 160 °C

4: H₂O; dimethylsulfoxide / porcine liver esterase

With sodium methylate; sodium chloride; Dowex H+ resin; In tetrahydrofuran; water; dimethyl sulfoxide;
DOI:10.1016/S0040-4039(00)92140-3

Reference yield:

: 20754-21-6
methyl 3-(4-chlorophenyl)propenoate

: 865366-99-0
(S)-3-(4-chlorophenyl)-glutaric acid monomethyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 85 percent / MeONa / tetrahydrofuran / Heating

2: 79 percent / NaCl / dimethylsulfoxide; H₂O / 160 °C

3: H₂O; dimethylsulfoxide / porcine liver esterase

With sodium methylate; sodium chloride; In tetrahydrofuran; water; dimethyl sulfoxide;
DOI:10.1016/S0040-4039(00)92140-3