(R)-3-(4-chlorophenyl)-glutaric acid monomethyl ester

Base Information

• Chemical Name: (R)-3-(4-chlorophenyl)-glutaric acid monomethyl ester
• CAS No.: 137310-16-8
• Molecular Formula: C₁₂H₁₃ClO₄
• Molecular Weight: 256.686
• Mol file: 137310-16-8.mol

Synonyms:(R)-3-(4-chlorophenyl)-glutaric acid monomethyl ester

Chemical Property of (R)-3-(4-chlorophenyl)-glutaric acid monomethyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (R)-3-(4-chlorophenyl)-glutaric acid monomethyl ester

There total 9 articles about (R)-3-(4-chlorophenyl)-glutaric acid monomethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

methanol (67-56-1) + 3-(4-chlorophenyl)glutaric anhydride (53911-68-5) → (R)-3-(4-chlorophenyl)-glutaric acid monomethyl ester (137310-16-8)

Guidance literature:

With N-((1S)-(6-methoxyquinolin-4-yl)((2S,4S,5R)-5-vinylquinuclidin-2-yl)methyl)-3,5-bis(trifluoromethyl)benzenesulfonamide; In tert-butyl methyl ether; at 20 ℃; for 1h; optical yield given as %ee; enantioselective reaction;

DOI:10.1002/adsc.201000289

Reference yield: 90.0%

dimethyl 3-(p-chlorophenyl)glutarate (137310-15-7) → (R)-3-(4-chlorophenyl)-glutaric acid monomethyl ester (137310-16-8)

Guidance literature:

dimethyl 3-(p-chlorophenyl)glutarate; With water; sodium hydroxide; chymotrypsin; at 20 ℃; for 72h; pH=7.7; aq. phosphate buffer; Enzymatic reaction;

With hydrogenchloride; In water; at 0 ℃; pH=2; optical yield given as %ee; enantioselective reaction;

DOI:10.1021/ol902820z

Reference yield:

methanol (67-56-1) + 3-(4-chlorophenyl)glutaric anhydride (53911-68-5) → (R)-3-(4-chlorophenyl)-glutaric acid monomethyl ester (137310-16-8) + (S)-3-(4-chlorophenyl)-glutaric acid monomethyl ester (865366-99-0)

Guidance literature:

With Novozym 435; In di-isopropyl ether; at 20 ℃; for 120h; Title compound not separated from byproducts;

DOI:10.1016/j.tetasy.2005.06.025

upstream raw materials:

dimethyl 3-(p-chlorophenyl)glutarate

methanol

3-(4-chlorophenyl)glutaric anhydride

3-(4-chlorophenyl)pentane-1,5-dioic acid

Downstream raw materials:

C₂₄H₂₄ClNO₃

C₂₄H₂₄ClNO₃

(R)-(-)-baclofen hydrochloride

(R)-baclofen