N-[2-({[(5-chloropyridin-2-yl)carbonyl]amino}methyl)phenyl]-5-methyl-4,5,6,7-tetrahydro[1,3]thiazolo[5,4-c]pyridine-2-carboxamide hydrochloride

Base Information

Chemical Name:N-[2-({[(5-chloropyridin-2-yl)carbonyl]amino}methyl)phenyl]-5-methyl-4,5,6,7-tetrahydro[1,3]thiazolo[5,4-c]pyridine-2-carboxamide hydrochloride
CAS No.:1286182-11-3
Molecular Formula:C₂₁H₂₀ClN₅O₂S*ClH
Molecular Weight:478.402
Hs Code.:

Synonyms:N-[2-({[(5-chloropyridin-2-yl)carbonyl]amino}methyl)phenyl]-5-methyl-4,5,6,7-tetrahydro[1,3]thiazolo[5,4-c]pyridine-2-carboxamide hydrochloride

Suppliers and Price of N-[2-({[(5-chloropyridin-2-yl)carbonyl]amino}methyl)phenyl]-5-methyl-4,5,6,7-tetrahydro[1,3]thiazolo[5,4-c]pyridine-2-carboxamide hydrochloride

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of N-[2-({[(5-chloropyridin-2-yl)carbonyl]amino}methyl)phenyl]-5-methyl-4,5,6,7-tetrahydro[1,3]thiazolo[5,4-c]pyridine-2-carboxamide hydrochloride

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of N-[2-({[(5-chloropyridin-2-yl)carbonyl]amino}methyl)phenyl]-5-methyl-4,5,6,7-tetrahydro[1,3]thiazolo[5,4-c]pyridine-2-carboxamide hydrochloride

There total 8 articles about N-[2-({[(5-chloropyridin-2-yl)carbonyl]amino}methyl)phenyl]-5-methyl-4,5,6,7-tetrahydro[1,3]thiazolo[5,4-c]pyridine-2-carboxamide hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1057855-29-4
N-[2-({[(5-chloropyridin-2-yl)carbonyl]amino}methyl)phenyl]-5-methyl-4,5,6,7-tetrahydro[1,3]thiazolo[5,4-c]pyridine-2-carboxamide

: 1286182-11-3
N-[2-({[(5-chloropyridin-2-yl)carbonyl]amino}methyl)phenyl]-5-methyl-4,5,6,7-tetrahydro[1,3]thiazolo[5,4-c]pyridine-2-carboxamide hydrochloride

Guidance literature:: With hydrogenchloride; In water;
DOI:10.1016/j.bmc.2011.01.035

Reference yield:

: 1072-98-6
5-chloro-2-pyridylamine

: 1286182-11-3
N-[2-({[(5-chloropyridin-2-yl)carbonyl]amino}methyl)phenyl]-5-methyl-4,5,6,7-tetrahydro[1,3]thiazolo[5,4-c]pyridine-2-carboxamide hydrochloride

Guidance literature:: Multi-step reaction with 4 steps

1.1: hydrogen bromide; bromine; sodium nitrite / water / -5 - 15 °C

2.1: n-butyllithium / diethyl ether; hexane / 2 h / -78 °C / Inert atmosphere

2.2: 2 h

3.1: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine / N,N-dimethyl-formamide / 2 h / 20 °C

4.1: hydrogenchloride / water

With hydrogenchloride; n-butyllithium; hydrogen bromide; bromine; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; sodium nitrite; In diethyl ether; hexane; water; N,N-dimethyl-formamide; 1.1: Sandmeyer reaction;
DOI:10.1016/j.bmc.2011.01.035

Reference yield:

: 40473-01-6
2-Bromo-5-chloro-pyridine

: 1286182-11-3
N-[2-({[(5-chloropyridin-2-yl)carbonyl]amino}methyl)phenyl]-5-methyl-4,5,6,7-tetrahydro[1,3]thiazolo[5,4-c]pyridine-2-carboxamide hydrochloride

Guidance literature:: Multi-step reaction with 3 steps

1.1: n-butyllithium / diethyl ether; hexane / 2 h / -78 °C / Inert atmosphere

1.2: 2 h

2.1: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine / N,N-dimethyl-formamide / 2 h / 20 °C

3.1: hydrogenchloride / water

With hydrogenchloride; n-butyllithium; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In diethyl ether; hexane; water; N,N-dimethyl-formamide;
DOI:10.1016/j.bmc.2011.01.035