3-(4-(METHYLSULFONYL)PHENYL)SERINE ETHYL ESTER

Base Information

• Chemical Name: 3-(4-(METHYLSULFONYL)PHENYL)SERINE ETHYL ESTER
• CAS No.: 31925-27-6
• Molecular Formula: C₁₂H₁₇NO₅S
• Molecular Weight: 287.337
• Mol file: 31925-27-6.mol

Synonyms:DL-Phenylalanine,b-hydroxy-4-(methylsulfonyl)-,ethyl ester, threo-; Serine, 3-[p-(methylsulfonyl)phenyl]-, ethyl ester,DL-threo- (8CI); DL-threo-b-(p-Methylsulfonylphenyl)serine ethyl ester

Chemical Property of 3-(4-(METHYLSULFONYL)PHENYL)SERINE ETHYL ESTER

Chemical Property:

• Vapor Pressure: 1.98E-11mmHg at 25°C
• Refractive Index: 1.554
• Boiling Point: 515oC at 760 mmHg
• PKA: 10.57±0.45(Predicted)
• Flash Point: 265.2oC
• PSA: 115.07000
• Density: 1.309
• LogP: 1.79500

Purity/Quality:

99% ^*data from raw suppliers

3-(4-(METHYLSULFONYL)PHENYL)SERINE ETHYL ESTER 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 3-(4-(METHYLSULFONYL)PHENYL)SERINE ETHYL ESTER

There total 4 articles about 3-(4-(METHYLSULFONYL)PHENYL)SERINE ETHYL ESTER which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.6%

para-methanesulfonylbenzaldehyde (5398-77-6) + glycine ethyl ester hydrochloride (623-33-6) → 3-(4-(methylsulfonyl)phenyl)serine ethyl ester (31925-27-6,31925-29-8,36983-12-7,100483-39-4)

Guidance literature:

With copper (II) carbonate hydroxide; ammonium hydroxide; potassium hydroxide; In ethanol; at 78 - 82 ℃; pH=10.5 - 11; Temperature; Reflux;

Reference yield: 97.0%

ethanol (64-17-5) + C10H12NO5S(1-)*0.5Cu(2+) → 3-(4-(methylsulfonyl)phenyl)serine ethyl ester (31925-27-6,31925-29-8,36983-12-7,100483-39-4)

Guidance literature:

With diethyl sulfate; at 20 ℃; Reagent/catalyst; Reflux;

Reference yield: 42.3%

ethanol (64-17-5) + para-methanesulfonylbenzaldehyde (5398-77-6) + glycine (56-40-6,18875-39-3,25718-94-9) → 3-(4-(methylsulfonyl)phenyl)serine ethyl ester (31925-27-6,31925-29-8,36983-12-7,100483-39-4)

Guidance literature:

para-methanesulfonylbenzaldehyde; glycine; With ammonium hydroxide; copper(II) sulfate; In water; at 50 ℃; for 22h; pH=9;

ethanol; With sulfuric acid; for 2.5h; Temperature; Reflux;

upstream raw materials:

ethanol

para-methanesulfonylbenzaldehyde

glycine ethyl ester hydrochloride

glycine

Downstream raw materials:

(2S,3R)-2-amino-3-hydroxy-3-(4-methylsulfonylphenyl)propionic acid ethyl ester

D-threo-p-methylsulfonylphenylserine ethyl ester

para-methanesulfonylbenzaldehyde

p-methylsulfonylbenzyl alcohol