Benzeneacetic acid, -alpha--(acetylamino)-4-methoxy--alpha--methyl-, (-alpha-R)-

Base Information

Chemical Name:Benzeneacetic acid, -alpha--(acetylamino)-4-methoxy--alpha--methyl-, (-alpha-R)-
CAS No.:959694-60-1
Molecular Formula:C₁₂H₁₅NO₄
Molecular Weight:237.255
Hs Code.:
Mol file:959694-60-1.mol

Synonyms:(R)-2-acetylamino-2-(4-methoxyphenyl)propanoic acid

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Chemical Property of Benzeneacetic acid, -alpha--(acetylamino)-4-methoxy--alpha--methyl-, (-alpha-R)-

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Technology Process of Benzeneacetic acid, -alpha--(acetylamino)-4-methoxy--alpha--methyl-, (-alpha-R)-

There total 2 articles about Benzeneacetic acid, -alpha--(acetylamino)-4-methoxy--alpha--methyl-, (-alpha-R)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 31.0%

: 197643-97-3
C₁₂H₁₅NO₄

: 959694-60-1
(R)-2-acetylamino-2-(4-methoxyphenyl)propanoic acid

Guidance literature:: C₁₂H₁₅NO₄; With (R)-1-phenyl-ethyl-amine; In ethanol; at 20 - 40 ℃; Inert atmosphere;

With hydrogenchloride; at 20 ℃; for 0.75h; pH=1; Inert atmosphere;
DOI:10.1021/jm300249m

Reference yield:

: 22927-78-2
5-(4-methoxyphenyl)-5-methyl-2,4-imidazolidinedione

: 959694-60-1
(R)-2-acetylamino-2-(4-methoxyphenyl)propanoic acid

Guidance literature:: Multi-step reaction with 2 steps

1.1: sodium hydroxide / 64 h / Inert atmosphere; Reflux

2.1: (R)-1-phenyl-ethyl-amine / ethanol / 20 - 40 °C / Inert atmosphere

2.2: 0.75 h / 20 °C / pH 1 / Inert atmosphere

With (R)-1-phenyl-ethyl-amine; sodium hydroxide; In ethanol;
DOI:10.1021/jm300249m