Phosphoric acid benzyl ester 2,3-dihydroxy-propyl ester methyl ester

Base Information

• Chemical Name: Phosphoric acid benzyl ester 2,3-dihydroxy-propyl ester methyl ester
• CAS No.: 183999-15-7
• Molecular Formula: C₁₁H₁₇O₆P
• Molecular Weight: 276.226
• Mol file: 183999-15-7.mol

Synonyms:Phosphoric acid benzyl ester 2,3-dihydroxy-propyl ester methyl ester

Chemical Property of Phosphoric acid benzyl ester 2,3-dihydroxy-propyl ester methyl ester

Chemical Property:

Purity/Quality:

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Technology Process of Phosphoric acid benzyl ester 2,3-dihydroxy-propyl ester methyl ester

There total 3 articles about Phosphoric acid benzyl ester 2,3-dihydroxy-propyl ester methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 53.0%

Phosphoric acid benzyl ester 2,2-dimethyl-[1,3]dioxolan-4-ylmethyl ester methyl ester (183999-14-6) → Phosphoric acid benzyl ester 2,3-dihydroxy-propyl ester methyl ester (183999-15-7)

Guidance literature:

With Dowex 50W-X₈ (acid form); for 3.5h; Ambient temperature;

DOI:10.1021/jm960434y

Reference yield:

Phosphorous acid benzyl ester 2,2-dimethyl-[1,3]dioxolan-4-ylmethyl ester methyl ester (1027989-03-2) → Phosphoric acid benzyl ester 2,3-dihydroxy-propyl ester methyl ester (183999-15-7)

Guidance literature:

Multi-step reaction with 2 steps

1: t-BuOOH / CH₂Cl₂; 2,2,4-trimethyl-pentane / 2 h / 0 - 25 °C

2: 53 percent / Dowex 50W-X₈ (acid form) / 3.5 h / Ambient temperature

With tert.-butylhydroperoxide; Dowex 50W-X₈ (acid form); In 2,2,4-trimethylpentane; dichloromethane;

DOI:10.1021/jm960434y

Reference yield:

benzyl alcohol (100-51-6,185532-71-2) → Phosphoric acid benzyl ester 2,3-dihydroxy-propyl ester methyl ester (183999-15-7)

Guidance literature:

Multi-step reaction with 3 steps

1: 1.) N,N-diiisopropylethylamine / 1.) CH₂Cl₂, -78 deg C, 1 h, 2.) CH₂Cl₂, from -78 deg C to 25 deg C, 2 h

2: t-BuOOH / CH₂Cl₂; 2,2,4-trimethyl-pentane / 2 h / 0 - 25 °C

3: 53 percent / Dowex 50W-X₈ (acid form) / 3.5 h / Ambient temperature

With tert.-butylhydroperoxide; Dowex 50W-X₈ (acid form); N-ethyl-N,N-diisopropylamine; In 2,2,4-trimethylpentane; dichloromethane;

DOI:10.1021/jm960434y

upstream raw materials:

Phosphoric acid benzyl ester 2,2-dimethyl-[1,3]dioxolan-4-ylmethyl ester methyl ester

Phosphorous acid benzyl ester 2,2-dimethyl-[1,3]dioxolan-4-ylmethyl ester methyl ester

benzyl alcohol

Downstream raw materials:

Hexanoic acid 2-(benzyloxy-methoxy-phosphoryloxy)-1-hexanoyloxymethyl-ethyl ester