Hexanoic acid 2-(benzyloxy-methoxy-phosphoryloxy)-1-hexanoyloxymethyl-ethyl ester

Base Information

• Chemical Name: Hexanoic acid 2-(benzyloxy-methoxy-phosphoryloxy)-1-hexanoyloxymethyl-ethyl ester
• CAS No.: 183999-16-8
• Molecular Formula: C₂₃H₃₇O₈P
• Molecular Weight: 472.516
• Mol file: 183999-16-8.mol

Synonyms:Hexanoic acid 2-(benzyloxy-methoxy-phosphoryloxy)-1-hexanoyloxymethyl-ethyl ester

Chemical Property of Hexanoic acid 2-(benzyloxy-methoxy-phosphoryloxy)-1-hexanoyloxymethyl-ethyl ester

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

Useful:

Technology Process of Hexanoic acid 2-(benzyloxy-methoxy-phosphoryloxy)-1-hexanoyloxymethyl-ethyl ester

There total 4 articles about Hexanoic acid 2-(benzyloxy-methoxy-phosphoryloxy)-1-hexanoyloxymethyl-ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

Hexanoyl chloride (142-61-0) + Phosphoric acid benzyl ester 2,3-dihydroxy-propyl ester methyl ester (183999-15-7) → Hexanoic acid 2-(benzyloxy-methoxy-phosphoryloxy)-1-hexanoyloxymethyl-ethyl ester (183999-16-8)

Guidance literature:

With N-ethyl-N,N-diisopropylamine; In dichloromethane; at 0 - 25 ℃; for 14h;

DOI:10.1021/jm960434y

Reference yield:

Phosphorous acid benzyl ester 2,2-dimethyl-[1,3]dioxolan-4-ylmethyl ester methyl ester (1027989-03-2) → Hexanoic acid 2-(benzyloxy-methoxy-phosphoryloxy)-1-hexanoyloxymethyl-ethyl ester (183999-16-8)

Guidance literature:

Multi-step reaction with 3 steps

1: t-BuOOH / CH₂Cl₂; 2,2,4-trimethyl-pentane / 2 h / 0 - 25 °C

2: 53 percent / Dowex 50W-X₈ (acid form) / 3.5 h / Ambient temperature

3: 81 percent / N,N-diisopropylethylamine / CH₂Cl₂ / 14 h / 0 - 25 °C

With tert.-butylhydroperoxide; Dowex 50W-X₈ (acid form); N-ethyl-N,N-diisopropylamine; In 2,2,4-trimethylpentane; dichloromethane;

DOI:10.1021/jm960434y

Reference yield:

Phosphoric acid benzyl ester 2,2-dimethyl-[1,3]dioxolan-4-ylmethyl ester methyl ester (183999-14-6) → Hexanoic acid 2-(benzyloxy-methoxy-phosphoryloxy)-1-hexanoyloxymethyl-ethyl ester (183999-16-8)

Guidance literature:

Multi-step reaction with 2 steps

1: 53 percent / Dowex 50W-X₈ (acid form) / 3.5 h / Ambient temperature

2: 81 percent / N,N-diisopropylethylamine / CH₂Cl₂ / 14 h / 0 - 25 °C

With Dowex 50W-X₈ (acid form); N-ethyl-N,N-diisopropylamine; In dichloromethane;

DOI:10.1021/jm960434y

upstream raw materials:

Hexanoyl chloride

Phosphoric acid benzyl ester 2,3-dihydroxy-propyl ester methyl ester

Phosphorous acid benzyl ester 2,2-dimethyl-[1,3]dioxolan-4-ylmethyl ester methyl ester

Phosphoric acid benzyl ester 2,2-dimethyl-[1,3]dioxolan-4-ylmethyl ester methyl ester