N-(2-Bromo-ethyl)-N-[2-(2-hydroxy-ethoxy)-ethyl]-4-methyl-benzenesulfonamide

Base Information

• Chemical Name: N-(2-Bromo-ethyl)-N-[2-(2-hydroxy-ethoxy)-ethyl]-4-methyl-benzenesulfonamide
• CAS No.: 123845-26-1
• Molecular Formula: C₁₃H₂₀BrNO₄S
• Molecular Weight: 366.276
• Mol file: 123845-26-1.mol

Synonyms:N-(2-Bromo-ethyl)-N-[2-(2-hydroxy-ethoxy)-ethyl]-4-methyl-benzenesulfonamide

Chemical Property of N-(2-Bromo-ethyl)-N-[2-(2-hydroxy-ethoxy)-ethyl]-4-methyl-benzenesulfonamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-(2-Bromo-ethyl)-N-[2-(2-hydroxy-ethoxy)-ethyl]-4-methyl-benzenesulfonamide

There total 2 articles about N-(2-Bromo-ethyl)-N-[2-(2-hydroxy-ethoxy)-ethyl]-4-methyl-benzenesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 33.0%

N-<2-(2-hydroxyethoxy)ethyl>-4-methylbenzenesulfonamide (783-88-0) + ethylene dibromide (106-93-4) → N-(2-Bromo-ethyl)-N-[2-(2-hydroxy-ethoxy)-ethyl]-4-methyl-benzenesulfonamide (123845-26-1)

Guidance literature:

With sodium hydride; In N,N-dimethyl-formamide; at 100 ℃; for 24h;

DOI:10.1016/S0040-4039(00)99455-3

Reference yield:

p-toluenesulfonyl chloride (98-59-9) → N-(2-Bromo-ethyl)-N-[2-(2-hydroxy-ethoxy)-ethyl]-4-methyl-benzenesulfonamide (123845-26-1)

Guidance literature:

Multi-step reaction with 2 steps

1: 93 percent

2: 33 percent / NaH / dimethylformamide / 24 h / 100 °C

With sodium hydride; In N,N-dimethyl-formamide;

DOI:10.1016/S0040-4039(00)99455-3

Reference yield: 28.0%

N-(2-Bromo-ethyl)-N-[2-(2-hydroxy-ethoxy)-ethyl]-4-methyl-benzenesulfonamide (123845-26-1) + N-[2-((2-Cyano-ethyl)-{2-[2-(tetrahydro-pyran-2-yloxy)-ethoxy]-ethyl}-amino)-ethyl]-4-methyl-benzenesulfonamide (123845-25-0) → C34H52N4O9S2 (123845-27-2)

Guidance literature:

With sodium hydride; In N,N-dimethyl-formamide; at 100 ℃; for 12h;

DOI:10.1016/S0040-4039(00)99455-3

upstream raw materials:

N-<2-(2-hydroxyethoxy)ethyl>-4-methylbenzenesulfonamide

ethylene dibromide

p-toluenesulfonyl chloride

Downstream raw materials:

C₃₄H₅₂N₄O₉S₂

C₂₉H₄₄N₄O₈S₂

Methanesulfonic acid 2-{2-[{2-[(2-{(2-cyano-ethyl)-[2-(2-methanesulfonyloxy-ethoxy)-ethyl]-amino}-ethyl)-(toluene-4-sulfonyl)-amino]-ethyl}-(toluene-4-sulfonyl)-amino]-ethoxy}-ethyl ester

3-[3,12,15,21-Tetrakis-(toluene-4-sulfonyl)-6,18-dioxa-3,9,12,15,21,27-hexaaza-bicyclo[21.3.1]heptacosa-1⁽²⁶⁾,23⁽²⁷⁾,24-trien-9-yl]-propionitrile