1-[4-(4,4,5,5-tetramethyl-[1 ,3,2]dioxaborolan-2-yl)phenyl]pyrrolidin-2-one

Base Information

• Chemical Name: 1-[4-(4,4,5,5-tetramethyl-[1 ,3,2]dioxaborolan-2-yl)phenyl]pyrrolidin-2-one
• CAS No.: 1003309-09-8
• Molecular Formula: C₁₆H₂₂BNO₃
• Molecular Weight: 287.167
• Mol file: 1003309-09-8.mol

Synonyms:1-[4-(4,4,5,5-tetramethyl-[1 ,3,2]dioxaborolan-2-yl)phenyl]pyrrolidin-2-one

Chemical Property of 1-[4-(4,4,5,5-tetramethyl-[1 ,3,2]dioxaborolan-2-yl)phenyl]pyrrolidin-2-one

Chemical Property:

• Boiling Point: 478.0±28.0 °C(Predicted)
• Density: 1.12±0.1 g/cm3(Predicted)

Purity/Quality:

97% ^*data from raw suppliers

1-(4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)pyrrolidin-2-one 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1-[4-(4,4,5,5-tetramethyl-[1 ,3,2]dioxaborolan-2-yl)phenyl]pyrrolidin-2-one

There total 6 articles about 1-[4-(4,4,5,5-tetramethyl-[1 ,3,2]dioxaborolan-2-yl)phenyl]pyrrolidin-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

5-(4-(2-oxopyrrolidin-1-yl)phenyl)-5H-thianthren-5-ium trifluoromethanesulfonate + bis(pinacol)diborane (73183-34-3) → 1-[4-(4,4,5,5-tetramethyl-[1 ,3,2]dioxaborolan-2-yl)phenyl]pyrrolidin-2-one (1003309-09-8)

Guidance literature:

With dmap; (4s,6s)-2,4,5,6-tetra(9H-carbazol-9-yl)isophthalonitrile; In acetonitrile; at 20 ℃; for 8h; Irradiation; Inert atmosphere;

DOI:10.1007/s11426-019-9652-x

Reference yield: 86.0%

1-(4-bromophenyl)pyrrolidin-2-one (7661-32-7) + bis(pinacol)diborane (73183-34-3) → 1-[4-(4,4,5,5-tetramethyl-[1 ,3,2]dioxaborolan-2-yl)phenyl]pyrrolidin-2-one (1003309-09-8)

Guidance literature:

With caesium carbonate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; In 1,4-dioxane; water; for 24h; Inert atmosphere; Reflux;

Reference yield: 67.0%

4-(2-oxopyrrolidin-1-yl)benzoic acid (36151-44-7) + bis(pinacol)diborane (73183-34-3) → 1-[4-(4,4,5,5-tetramethyl-[1 ,3,2]dioxaborolan-2-yl)phenyl]pyrrolidin-2-one (1003309-09-8)

Guidance literature:

With palladium diacetate; 2,2-dimethylpropanoic anhydride; triethylamine; 1,4-di(diphenylphosphino)-butane; In 1,4-dioxane; at 160 ℃; for 15h;

DOI:10.1002/anie.201810145

upstream raw materials:

1-(4-bromophenyl)pyrrolidin-2-one

bis(pinacol)diborane

4-(2-oxopyrrolidin-1-yl)benzoic acid

1-phenylpyrrolidin-2-one

Downstream raw materials:

C₂₅H₁₉FN₄O

C₂₅H₂₀N₄O

1-(2-oxopyrrolidin-1-yl)-4-iodobenzene

N-(4-methoxyphenyl)-2-pyrrolidinone