(S)-2-{[(S)-2-((S)-2-Benzyloxycarbonylamino-3,3-dimethyl-butyryl)-1,2,3,4-tetrahydro-isoquinoline-3-carbonyl]-amino}-4-methoxy-butyric acid tert-butyl ester

Base Information

Chemical Name:(S)-2-{[(S)-2-((S)-2-Benzyloxycarbonylamino-3,3-dimethyl-butyryl)-1,2,3,4-tetrahydro-isoquinoline-3-carbonyl]-amino}-4-methoxy-butyric acid tert-butyl ester
CAS No.:1027187-22-9
Molecular Formula:C₃₃H₄₅N₃O₇
Molecular Weight:595.736
Hs Code.:

(S)-2-{[(S)-2-((S)-2-Benzyloxycarbonylamino-3,3-dimethyl-butyryl)-1,2,3,4-tetrahydro-isoquinoline-3-carbonyl]-amino}-4-methoxy-butyric acid tert-butyl ester

Synonyms:(S)-2-{[(S)-2-((S)-2-Benzyloxycarbonylamino-3,3-dimethyl-butyryl)-1,2,3,4-tetrahydro-isoquinoline-3-carbonyl]-amino}-4-methoxy-butyric acid tert-butyl ester

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Chemical Property of (S)-2-{[(S)-2-((S)-2-Benzyloxycarbonylamino-3,3-dimethyl-butyryl)-1,2,3,4-tetrahydro-isoquinoline-3-carbonyl]-amino}-4-methoxy-butyric acid tert-butyl ester

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Technology Process of (S)-2-{[(S)-2-((S)-2-Benzyloxycarbonylamino-3,3-dimethyl-butyryl)-1,2,3,4-tetrahydro-isoquinoline-3-carbonyl]-amino}-4-methoxy-butyric acid tert-butyl ester

There total 4 articles about (S)-2-{[(S)-2-((S)-2-Benzyloxycarbonylamino-3,3-dimethyl-butyryl)-1,2,3,4-tetrahydro-isoquinoline-3-carbonyl]-amino}-4-methoxy-butyric acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 62965-10-0
(S)-N-carbobenzoxy-tert-butylleucine

: 1027187-22-9
(S)-2-{[(S)-2-((S)-2-Benzyloxycarbonylamino-3,3-dimethyl-butyryl)-1,2,3,4-tetrahydro-isoquinoline-3-carbonyl]-amino}-4-methoxy-butyric acid tert-butyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 45 percent / N,N-diisopropylethylamine, Bop-Cl / CH₂Cl₂ / a) from 0 deg C to 5 deg C, 2 h, b) 5 deg C, 16 h

2: 100 percent / 1 N NaOH / methanol / 2 h / Ambient temperature

3: N,N-diisopropylethylamine, Bop / acetonitrile; dimethylformamide / 16 h / Ambient temperature

With sodium hydroxide; bis-(2-oxo-3-oxazolidinyl)phosphoryl chloride; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; In methanol; dichloromethane; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1021/jm950642a

Reference yield:

: 78183-55-8
(S)-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid, methyl ester, hydrochloride

: 1027187-22-9
(S)-2-{[(S)-2-((S)-2-Benzyloxycarbonylamino-3,3-dimethyl-butyryl)-1,2,3,4-tetrahydro-isoquinoline-3-carbonyl]-amino}-4-methoxy-butyric acid tert-butyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 45 percent / N,N-diisopropylethylamine, Bop-Cl / CH₂Cl₂ / a) from 0 deg C to 5 deg C, 2 h, b) 5 deg C, 16 h

2: 100 percent / 1 N NaOH / methanol / 2 h / Ambient temperature

3: N,N-diisopropylethylamine, Bop / acetonitrile; dimethylformamide / 16 h / Ambient temperature

With sodium hydroxide; bis-(2-oxo-3-oxazolidinyl)phosphoryl chloride; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; In methanol; dichloromethane; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1021/jm950642a

Reference yield:

: 166169-81-9
(S)-1,2,3,4-tetrahydro-2-<3-methyl-N-<(phenylmethoxy)-carbonyl>-L-valyl>-3-isoquinolinecarboxylic acetic acid, methyl ester

: 1027187-22-9
(S)-2-{[(S)-2-((S)-2-Benzyloxycarbonylamino-3,3-dimethyl-butyryl)-1,2,3,4-tetrahydro-isoquinoline-3-carbonyl]-amino}-4-methoxy-butyric acid tert-butyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 100 percent / 1 N NaOH / methanol / 2 h / Ambient temperature

2: N,N-diisopropylethylamine, Bop / acetonitrile; dimethylformamide / 16 h / Ambient temperature

With sodium hydroxide; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; In methanol; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1021/jm950642a