4-[(E)-2-(3-methoxyphenyl)vinyl]phenol

Base Information

• Chemical Name: 4-[(E)-2-(3-methoxyphenyl)vinyl]phenol
• CAS No.: 190182-38-8
• Molecular Formula: C₁₅H₁₄O₂
• Molecular Weight: 226.275
• European Community (EC) Number: 826-873-5
• Nikkaji Number: J303.858K
• Metabolomics Workbench ID: 137626
• ChEMBL ID: CHEMBL476678
• Mol file: 190182-38-8.mol

Synonyms:4-[(E)-2-(3-methoxyphenyl)vinyl]phenol;128294-46-2;(E)-4-(3-Methoxystyryl)phenol;4-[(E)-2-(3-methoxyphenyl)ethenyl]phenol;(E)-5-METHOXY-4'-STILBENOL;190182-38-8;NSC684913;4-(3-Methoxystyryl)phenol;CHEMBL476678;SCHEMBL4108317;SCHEMBL9482129;3-methoxy-4'-hydroxy-(e)-stilbene;BDBM50140142;MFCD00045789;4-(2-(3-Methoxyphenyl)vinyl)phenol;AKOS005173946;4-[2-(3-methoxyphenyl)ethenyl]phenol;(E)-5-METHOXY-4''-STILBENOL;LS-04326;CS-0303050;CS-0369242;4-[(1E)-2-(3-methoxyphenyl)ethenyl]phenol;EN300-223181;EN300-6480673;Z2106461173

Chemical Property of 4-[(E)-2-(3-methoxyphenyl)vinyl]phenol

Chemical Property:

• XLogP3: 4
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 3
• Exact Mass: 226.099379685
• Heavy Atom Count: 17
• Complexity: 241

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Canonical SMILES: COC1=CC=CC(=C1)C=CC2=CC=C(C=C2)O
• Isomeric SMILES: COC1=CC=CC(=C1)/C=C/C2=CC=C(C=C2)O

Technology Process of 4-[(E)-2-(3-methoxyphenyl)vinyl]phenol

There total 1 articles about 4-[(E)-2-(3-methoxyphenyl)vinyl]phenol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

3-methoxystyrene (626-20-0) + p-Iodophenol (540-38-5) → 12-hydroxy-3-methoxystilbene (190182-38-8)

Guidance literature:

With triethanolamine; palladium diacetate; at 100 ℃; for 1h; Inert atmosphere;

DOI:10.1016/j.bmcl.2015.12.065

Reference yield: 52.0%

12-hydroxy-3-methoxystilbene (190182-38-8) + 3-(dimethylamino)propyl chloride hydrochloride (5407-04-5) → (E)-3-(4-(3-methoxystyryl)phenoxy)-N,N-dimethylpropan-1-amine

Guidance literature:

12-hydroxy-3-methoxystilbene; With potassium carbonate; In N,N-dimethyl-formamide; at 90 ℃; for 0.5h;

3-(dimethylamino)propyl chloride hydrochloride; In N,N-dimethyl-formamide; at 90 ℃; for 16h;

DOI:10.1124/jpet.116.239574

Reference yield: 48.0%

12-hydroxy-3-methoxystilbene (190182-38-8) → C30H26O4

Guidance literature:

With silver(I) acetate; In dichloromethane; at 20 ℃; for 24h;

DOI:10.1002/chem.200801575

upstream raw materials:

3-methoxystyrene

p-Iodophenol

Downstream raw materials:

3,4'-Dihydroxystilben