Technology Process of 3-((4-((4-nitrophenoxy)methyl)-1H-1,2,3-triazol-1-yl)methyl)-N-sec-butylbenzamidine
There total 5 articles about 3-((4-((4-nitrophenoxy)methyl)-1H-1,2,3-triazol-1-yl)methyl)-N-sec-butylbenzamidine which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
copper(ll) sulfate pentahydrate; sodium L-ascorbate;
In
water; tert-butyl alcohol;
at 60 ℃;
for 48h;
DOI:10.3390/molecules19055674
- Guidance literature:
-
Multi-step reaction with 2 steps
1: potassium carbonate / acetone / 3.75 h / 20 °C / Reflux
2: copper(ll) sulfate pentahydrate; sodium L-ascorbate / water; tert-butyl alcohol / 48 h / 60 °C
With
copper(ll) sulfate pentahydrate; potassium carbonate; sodium L-ascorbate;
In
water; acetone; tert-butyl alcohol;
DOI:10.3390/molecules19055674
- Guidance literature:
-
Multi-step reaction with 4 steps
1: sodium azide / N,N-dimethyl-formamide; water / 1.5 h / 10 - 30 °C
2: hydrogenchloride / 168 h / 20 °C / Cooling with ice
3: methanol / 30 °C
4: copper(ll) sulfate pentahydrate; sodium L-ascorbate / water; tert-butyl alcohol / 48 h / 60 °C
With
hydrogenchloride; sodium azide; copper(ll) sulfate pentahydrate; sodium L-ascorbate;
In
methanol; water; N,N-dimethyl-formamide; tert-butyl alcohol;
2: |Pinner Amidine Synthesis;
DOI:10.3390/molecules19055674
