2,4-diamino-6-<2-(4-carbethoxyphenyl)ethyl>-5,6,7,8-tetrahydropyrido<4,3-d>pyrimidine

Base Information

Chemical Name:2,4-diamino-6-<2-(4-carbethoxyphenyl)ethyl>-5,6,7,8-tetrahydropyrido<4,3-d>pyrimidine
CAS No.:121187-74-4
Molecular Formula:C₁₈H₂₃N₅O₂
Molecular Weight:341.413
Hs Code.:

Synonyms:2,4-diamino-6-<2-(4-carbethoxyphenyl)ethyl>-5,6,7,8-tetrahydropyrido<4,3-d>pyrimidine

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Chemical Property of 2,4-diamino-6-<2-(4-carbethoxyphenyl)ethyl>-5,6,7,8-tetrahydropyrido<4,3-d>pyrimidine

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Technology Process of 2,4-diamino-6-<2-(4-carbethoxyphenyl)ethyl>-5,6,7,8-tetrahydropyrido<4,3-d>pyrimidine

There total 8 articles about 2,4-diamino-6-<2-(4-carbethoxyphenyl)ethyl>-5,6,7,8-tetrahydropyrido<4,3-d>pyrimidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 26.0%

: 74003-31-9
4-bromoethylbenzoic acid ethyl ester

: 121187-73-3
2,4-diamino-5,6,7,8-tetrahydropyrido<4,3-d>pyrimidine dihydrochloride

: 121187-74-4
2,4-diamino-6-<2-(4-carbethoxyphenyl)ethyl>-5,6,7,8-tetrahydropyrido<4,3-d>pyrimidine

Guidance literature:: With sodium acetate; sodium iodide; In dimethyl sulfoxide; at 70 ℃; for 50h;
DOI:10.1002/jhet.5570260247

Reference yield:

: 3612-20-2
1-phenylmethyl-4-piperidone

: 121187-74-4
2,4-diamino-6-<2-(4-carbethoxyphenyl)ethyl>-5,6,7,8-tetrahydropyrido<4,3-d>pyrimidine

Guidance literature:: Multi-step reaction with 3 steps

1: 8.7 percent / dimethylsulfoxide / 0.33 h / Heating

2: 62 percent / 1 N HCl, H₂ / 10 percent Pd/C / propan-2-ol; H₂O

3: 26 percent / NaOAc, NaI / dimethylsulfoxide / 50 h / 70 °C

With hydrogenchloride; hydrogen; sodium acetate; sodium iodide; palladium on activated charcoal; In water; dimethyl sulfoxide; isopropyl alcohol;
DOI:10.1002/jhet.5570260247

Reference yield:

: 1029-52-3
2-amino-6-benzyl-5,6,7,8-tetrahydropyrido<4,3-d>pyrimidin-4(3H)-one

: 121187-74-4
2,4-diamino-6-<2-(4-carbethoxyphenyl)ethyl>-5,6,7,8-tetrahydropyrido<4,3-d>pyrimidine

Guidance literature:: Multi-step reaction with 5 steps

1: 73 percent / POCl₃, DMF / 3.5 h / Heating

2: 71 percent / NH₂NH₂ / H₂O; ethanol / 17 h / Ambient temperature

3: 81 percent / 1 N HCl, H₂ / 10 percent Pd/C / ethanol

4: 92 percent / H₂ / Davison sponge nickel / ethanol; H₂O / 22 h

5: 26 percent / NaOAc, NaI / dimethylsulfoxide / 50 h / 70 °C

With hydrogenchloride; hydrogen; sodium acetate; N,N-dimethyl-formamide; sodium iodide; hydrazine; trichlorophosphate; palladium on activated charcoal; Davison sponge nickel; In ethanol; water; dimethyl sulfoxide;
DOI:10.1002/jhet.5570260247