3,3-dimethyl-2-phenylsulphonyl-2-phenylthiooxirane

Base Information

• Chemical Name: 3,3-dimethyl-2-phenylsulphonyl-2-phenylthiooxirane
• CAS No.: 120346-67-0
• Molecular Formula: C₁₆H₁₆O₃S₂
• Molecular Weight: 320.433
• Mol file: 120346-67-0.mol

Synonyms:3,3-dimethyl-2-phenylsulphonyl-2-phenylthiooxirane

Chemical Property of 3,3-dimethyl-2-phenylsulphonyl-2-phenylthiooxirane

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

Useful:

Technology Process of 3,3-dimethyl-2-phenylsulphonyl-2-phenylthiooxirane

There total 3 articles about 3,3-dimethyl-2-phenylsulphonyl-2-phenylthiooxirane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

chloromethyl phenyl sulfone (7205-98-3) → 3,3-dimethyl-2-phenylsulphonyl-2-phenylthiooxirane (120346-67-0)

Guidance literature:

Multi-step reaction with 2 steps

1: 96 percent / aq. sodium hydroxide, tetrabutylammonium bromide / CH₂Cl₂ / a) 0 deg C, 2 h, b) room temperature, 24 h

2: 1) butyllithium / 1) THF, pentane, hexanes, -105 deg C, 2) -102 deg C, 5 min

With sodium hydroxide; n-butyllithium; tetrabutylammomium bromide; In dichloromethane;

DOI:10.1039/P19910003091

Reference yield:

3,3-dimethyl-2-phenylsulphonyloxirane (28937-59-9) + diphenyldisulfane (882-33-7) → (R)-2-Benzenesulfonyl-3,3-dimethyl-2-phenylsulfanyl-oxirane (120346-67-0)

Guidance literature:

With n-butyllithium; Yield given. Multistep reaction; 1) -102 deg C;

DOI:10.1016/S0040-4039(00)80635-8

Reference yield:

3,3-dimethyl-2-phenylsulphonyloxirane (28937-59-9) + diphenyldisulfane (882-33-7) → 3,3-dimethyl-2-phenylsulphonyl-2-phenylthiooxirane (120346-67-0)

Guidance literature:

With n-butyllithium; Yield given. Multistep reaction; 1) THF, pentane, hexanes, -105 deg C, 2) -102 deg C, 5 min;

DOI:10.1039/P19910003091

upstream raw materials:

3,3-dimethyl-2-phenylsulphonyloxirane

diphenyldisulfane

chloromethyl phenyl sulfone

Downstream raw materials:

S-phenyl 2-bromo-2-methyl(thiopropanoate)

Refernces

• 1、 Hewkin, Cheryl T.,Jackson, Richard F. W.,Clegg, William. "PREPARATION OF 1-PHENYLSULPHONYL-1-PHENYLTHIO EPOXIDES: CONVENIENT PRECURSORS TO α-HALO S-PHENYL THIO ESTERS". . p. 4889 - 4892. Retrieved 2007/10/02.