1-(1H-1,2,4-triazol-1-yl)-2-(2,4-difluorophenyl)-3-(iso-propylamino)-propan-2-ol

Base Information

Chemical Name:1-(1H-1,2,4-triazol-1-yl)-2-(2,4-difluorophenyl)-3-(iso-propylamino)-propan-2-ol
CAS No.:1122509-87-8
Molecular Formula:C₁₄H₁₈F₂N₄O
Molecular Weight:296.32
Hs Code.:

Synonyms:1-(1H-1,2,4-triazol-1-yl)-2-(2,4-difluorophenyl)-3-(iso-propylamino)-propan-2-ol

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Chemical Property of 1-(1H-1,2,4-triazol-1-yl)-2-(2,4-difluorophenyl)-3-(iso-propylamino)-propan-2-ol

Chemical Property:

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Technology Process of 1-(1H-1,2,4-triazol-1-yl)-2-(2,4-difluorophenyl)-3-(iso-propylamino)-propan-2-ol

There total 5 articles about 1-(1H-1,2,4-triazol-1-yl)-2-(2,4-difluorophenyl)-3-(iso-propylamino)-propan-2-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

: 75-31-0
isopropylamine

: 86386-77-8
1-[2-(2,4-difluorophenyl)-2,3-epoxypropyl]-1H-1,2,4-triazole methanesulfonate

: 1122509-87-8
1-(1H-1,2,4-triazol-1-yl)-2-(2,4-difluorophenyl)-3-(iso-propylamino)-propan-2-ol

Guidance literature:: With triethylamine; In ethanol; for 6h; Reflux;
DOI:10.1016/j.ejmech.2010.07.002

Reference yield:

: 86386-76-7,123632-22-4,141113-42-0,150024-48-9
1-[2-(2,4-difluorophenyl)-2,3-epoxypropyl]-1H-1,2,4-triazole

: 75-31-0
isopropylamine

: 1122509-87-8
1-(1H-1,2,4-triazol-1-yl)-2-(2,4-difluorophenyl)-3-(iso-propylamino)-propan-2-ol

Guidance literature:: With triethylamine; In ethanol; at 80 ℃;
DOI:10.1007/s10600-021-03552-2

Reference yield:

: 372-18-9
1,3-Difluorobenzene

: 1122509-87-8
1-(1H-1,2,4-triazol-1-yl)-2-(2,4-difluorophenyl)-3-(iso-propylamino)-propan-2-ol

Guidance literature:: Multi-step reaction with 4 steps

1: aluminum (III) chloride

2: potassium carbonate; N-benzyl-N,N,N-triethylammonium chloride / dichloromethane / 17 h / 0 - 20 °C

3: cetyltrimethylammonim bromide; sodium hydroxide / toluene

4: ethanol / Heating

With aluminum (III) chloride; N-benzyl-N,N,N-triethylammonium chloride; cetyltrimethylammonim bromide; potassium carbonate; sodium hydroxide; In ethanol; dichloromethane; toluene; 1: |Friedel-Crafts Acylation;