4-bromopyridine-2,6-dicarboxylic acid bis[((S)-2-hydroxy-1-phenylethyl)amide]

Base Information

Chemical Name:4-bromopyridine-2,6-dicarboxylic acid bis[((S)-2-hydroxy-1-phenylethyl)amide]
CAS No.:1262239-72-4
Molecular Formula:C₂₃H₂₂BrN₃O₄
Molecular Weight:484.349
Hs Code.:

Synonyms:4-bromopyridine-2,6-dicarboxylic acid bis[((S)-2-hydroxy-1-phenylethyl)amide]

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Chemical Property of 4-bromopyridine-2,6-dicarboxylic acid bis[((S)-2-hydroxy-1-phenylethyl)amide]

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Technology Process of 4-bromopyridine-2,6-dicarboxylic acid bis[((S)-2-hydroxy-1-phenylethyl)amide]

There total 3 articles about 4-bromopyridine-2,6-dicarboxylic acid bis[((S)-2-hydroxy-1-phenylethyl)amide] which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

: 20989-17-7
(2S)-2-phenylglycinol

: 162102-79-6
dimethyl 4-bromo-2,6-pyridinedicarboxylate

: 1262239-72-4
4-bromopyridine-2,6-dicarboxylic acid bis[((S)-2-hydroxy-1-phenylethyl)amide]

Guidance literature:: In methanol; at 115 ℃; for 12h; Sealed tube;
DOI:10.1016/j.tet.2019.04.023

Reference yield:

: 138-60-3
chelidamic acid

: 1262239-72-4
4-bromopyridine-2,6-dicarboxylic acid bis[((S)-2-hydroxy-1-phenylethyl)amide]

Guidance literature:: Multi-step reaction with 3 steps

1: sulfuric acid / 20 °C / Reflux

2: phosphorus tribromide / chloroform / 3 h / 90 °C

3: methanol / 5 h / 115 °C

With sulfuric acid; phosphorus tribromide; In methanol; chloroform;
DOI:10.1021/ol102759w

Reference yield:

: 19872-91-4
dimethyl 4-hydroxypyridine-2,6-dicarboxylate

: 1262239-72-4
4-bromopyridine-2,6-dicarboxylic acid bis[((S)-2-hydroxy-1-phenylethyl)amide]

Guidance literature:: Multi-step reaction with 2 steps

1: phosphorus tribromide / chloroform / 3 h / 90 °C

2: methanol / 5 h / 115 °C

With phosphorus tribromide; In methanol; chloroform;
DOI:10.1021/ol102759w