(R)-{N-3-[3,5-difluoro-4-(7,7-ethylenedioxy-5-azaspiro[2,4]heptan-5-yl)phenyl]-2-oxo-5-oxazolidinyl}methyl azide

Base Information

Chemical Name:(R)-{N-3-[3,5-difluoro-4-(7,7-ethylenedioxy-5-azaspiro[2,4]heptan-5-yl)phenyl]-2-oxo-5-oxazolidinyl}methyl azide
CAS No.:1214265-40-3
Molecular Formula:C₁₈H₁₉F₂N₅O₄
Molecular Weight:407.377
Hs Code.:

Synonyms:(R)-{N-3-[3,5-difluoro-4-(7,7-ethylenedioxy-5-azaspiro[2,4]heptan-5-yl)phenyl]-2-oxo-5-oxazolidinyl}methyl azide

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Chemical Property of (R)-{N-3-[3,5-difluoro-4-(7,7-ethylenedioxy-5-azaspiro[2,4]heptan-5-yl)phenyl]-2-oxo-5-oxazolidinyl}methyl azide

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Technology Process of (R)-{N-3-[3,5-difluoro-4-(7,7-ethylenedioxy-5-azaspiro[2,4]heptan-5-yl)phenyl]-2-oxo-5-oxazolidinyl}methyl azide

There total 7 articles about (R)-{N-3-[3,5-difluoro-4-(7,7-ethylenedioxy-5-azaspiro[2,4]heptan-5-yl)phenyl]-2-oxo-5-oxazolidinyl}methyl azide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 65.0%

: 1214265-39-0
(R)-{N-3-[3,5-difluoro-4-(7,7-ethylenedioxy-5-azaspiro[2,4]heptan-5-yl)phenyl]-2-oxo-5-oxazolidinyl}methyl methanesulfonate

: 1214265-40-3
(R)-{N-3-[3,5-difluoro-4-(7,7-ethylenedioxy-5-azaspiro[2,4]heptan-5-yl)phenyl]-2-oxo-5-oxazolidinyl}methyl azide

Guidance literature:: With sodium azide; In N,N-dimethyl-formamide; at 60 ℃; for 16h;

Reference yield:

: 1214265-35-6
3,5-difluoro-4-(7,7-ethylenedioxy-5-azaspiro[2,4]heptan-5-yl)-nitrobenzene

: 1214265-40-3
(R)-{N-3-[3,5-difluoro-4-(7,7-ethylenedioxy-5-azaspiro[2,4]heptan-5-yl)phenyl]-2-oxo-5-oxazolidinyl}methyl azide

Guidance literature:: Multi-step reaction with 5 steps

1.1: hydrogen / palladium on activated charcoal / tetrahydrofuran / 2 h / 2068.65 Torr

2.1: sodium hydrogencarbonate / water; acetone / 20 °C / Ice bath

3.1: n-butyllithium / tetrahydrofuran; hexane / -78 °C

3.2: -78 - 20 °C

4.1: triethylamine / dichloromethane / 20 °C / Ice bath

5.1: sodium azide / N,N-dimethyl-formamide / 16 h / 60 °C

With n-butyllithium; sodium azide; hydrogen; sodium hydrogencarbonate; triethylamine; palladium on activated charcoal; In tetrahydrofuran; hexane; dichloromethane; water; N,N-dimethyl-formamide; acetone;

Reference yield:

: 129321-60-4
5,8-dioxa-10-azadispiro[2.0.44.33]undecane

: 1214265-40-3
(R)-{N-3-[3,5-difluoro-4-(7,7-ethylenedioxy-5-azaspiro[2,4]heptan-5-yl)phenyl]-2-oxo-5-oxazolidinyl}methyl azide

Guidance literature:: Multi-step reaction with 6 steps

1.1: acetonitrile / Reflux

2.1: hydrogen / palladium on activated charcoal / tetrahydrofuran / 2 h / 2068.65 Torr

3.1: sodium hydrogencarbonate / water; acetone / 20 °C / Ice bath

4.1: n-butyllithium / tetrahydrofuran; hexane / -78 °C

4.2: -78 - 20 °C

5.1: triethylamine / dichloromethane / 20 °C / Ice bath

6.1: sodium azide / N,N-dimethyl-formamide / 16 h / 60 °C

With n-butyllithium; sodium azide; hydrogen; sodium hydrogencarbonate; triethylamine; palladium on activated charcoal; In tetrahydrofuran; hexane; dichloromethane; water; N,N-dimethyl-formamide; acetone; acetonitrile;