(S)-N-{{3-[3,5-difluoro-4-(7-amino-5-azaspiro[2,4]heptan-5-yl)phenyl]-2-oxo-5-oxazolidinyl}methyl}acetamide

Base Information

Chemical Name:(S)-N-{{3-[3,5-difluoro-4-(7-amino-5-azaspiro[2,4]heptan-5-yl)phenyl]-2-oxo-5-oxazolidinyl}methyl}acetamide
CAS No.:1214265-34-5
Molecular Formula:C₁₈H₂₂F₂N₄O₃
Molecular Weight:380.394
Hs Code.:

Synonyms:(S)-N-{{3-[3,5-difluoro-4-(7-amino-5-azaspiro[2,4]heptan-5-yl)phenyl]-2-oxo-5-oxazolidinyl}methyl}acetamide

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Chemical Property of (S)-N-{{3-[3,5-difluoro-4-(7-amino-5-azaspiro[2,4]heptan-5-yl)phenyl]-2-oxo-5-oxazolidinyl}methyl}acetamide

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Technology Process of (S)-N-{{3-[3,5-difluoro-4-(7-amino-5-azaspiro[2,4]heptan-5-yl)phenyl]-2-oxo-5-oxazolidinyl}methyl}acetamide

There total 15 articles about (S)-N-{{3-[3,5-difluoro-4-(7-amino-5-azaspiro[2,4]heptan-5-yl)phenyl]-2-oxo-5-oxazolidinyl}methyl}acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 34.0%

: 1214265-44-7
C₁₈H₂₀F₂N₆O₃

: 64-19-7,77671-22-8
acetic acid

: 1214265-34-5
(S)-N-{{3-[3,5-difluoro-4-(7-amino-5-azaspiro[2,4]heptan-5-yl)phenyl]-2-oxo-5-oxazolidinyl}methyl}acetamide

Guidance literature:: C₁₈H₂₀F₂N₆O₃; With hydrogen; palladium 10% on activated carbon; In ethyl acetate; at 20 ℃; for 14h; under 760.051 Torr;

acetic acid; With pyridine; at 0 - 20 ℃; for 2.5h; Inert atmosphere;

Reference yield:

: 1214265-44-7
C₁₈H₂₀F₂N₆O₃

: 1214265-34-5
(S)-N-{{3-[3,5-difluoro-4-(7-amino-5-azaspiro[2,4]heptan-5-yl)phenyl]-2-oxo-5-oxazolidinyl}methyl}acetamide

Guidance literature:: With hydrogen; palladium on activated charcoal; In ethyl acetate; at 20 ℃; for 14h; under 760.051 Torr;

Reference yield:

: 1214265-35-6
3,5-difluoro-4-(7,7-ethylenedioxy-5-azaspiro[2,4]heptan-5-yl)-nitrobenzene

: 1214265-34-5
(S)-N-{{3-[3,5-difluoro-4-(7-amino-5-azaspiro[2,4]heptan-5-yl)phenyl]-2-oxo-5-oxazolidinyl}methyl}acetamide

Guidance literature:: Multi-step reaction with 12 steps

1.1: hydrogen / palladium on activated charcoal / tetrahydrofuran / 2 h / 2068.65 Torr

2.1: sodium hydrogencarbonate / water; acetone / 20 °C / Ice bath

3.1: n-butyllithium / tetrahydrofuran; hexane / -78 °C

3.2: -78 - 20 °C

4.1: triethylamine / dichloromethane / 20 °C / Ice bath

5.1: sodium azide / N,N-dimethyl-formamide / 16 h / 60 °C

6.1: hydrogen / palladium on activated charcoal / ethyl acetate / 14 h / 20 °C / 760.05 Torr

7.1: pyridine / 2.5 h / 0 - 20 °C / Inert atmosphere

8.1: water; toluene-4-sulfonic acid / acetone / 3 h / Reflux

9.1: sodium tetrahydroborate / tetrahydrofuran / Ice bath

10.1: triethylamine / dichloromethane / 20 °C / Ice bath

11.1: sodium azide / N,N-dimethyl-formamide / 16 h / 60 °C

12.1: hydrogen / palladium on activated charcoal / ethyl acetate / 14 h / 20 °C / 760.05 Torr

With pyridine; sodium tetrahydroborate; n-butyllithium; sodium azide; water; hydrogen; sodium hydrogencarbonate; toluene-4-sulfonic acid; triethylamine; palladium on activated charcoal; In tetrahydrofuran; hexane; dichloromethane; water; ethyl acetate; N,N-dimethyl-formamide; acetone;