methyl 3-acetyl-1-benzhydryl-α-(methylsulfanyl)-5-(trichloroacetyl)-1,4-dihydropyridine-4-acetate

Base Information

Chemical Name:methyl 3-acetyl-1-benzhydryl-α-(methylsulfanyl)-5-(trichloroacetyl)-1,4-dihydropyridine-4-acetate
CAS No.:754215-70-8
Molecular Formula:C₂₆H₂₄Cl₃NO₄S
Molecular Weight:552.906
Hs Code.:

Synonyms:methyl 3-acetyl-1-benzhydryl-α-(methylsulfanyl)-5-(trichloroacetyl)-1,4-dihydropyridine-4-acetate

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Chemical Property of methyl 3-acetyl-1-benzhydryl-α-(methylsulfanyl)-5-(trichloroacetyl)-1,4-dihydropyridine-4-acetate

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Technology Process of methyl 3-acetyl-1-benzhydryl-α-(methylsulfanyl)-5-(trichloroacetyl)-1,4-dihydropyridine-4-acetate

There total 3 articles about methyl 3-acetyl-1-benzhydryl-α-(methylsulfanyl)-5-(trichloroacetyl)-1,4-dihydropyridine-4-acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

: 16630-66-3
methyl 2-(methylthio)acetate

: 3-acetyl-1-benzhydrylpyridinium bromide

: 4124-31-6
trichloroacetic acid anhydride

: 754215-70-8
methyl 3-acetyl-1-benzhydryl-α-(methylsulfanyl)-5-(trichloroacetyl)-1,4-dihydropyridine-4-acetate

Guidance literature:: methyl 2-(methylthio)acetate; With lithium diisopropyl amide; In tetrahydrofuran; cyclohexane; at -78 ℃; for 0.5h;

3-acetyl-1-benzhydrylpyridinium bromide; In tetrahydrofuran; cyclohexane; at -78 - -40 ℃;

trichloroacetic acid anhydride; With triethylamine; In tetrahydrofuran; cyclohexane; at 20 ℃; for 12h; Further stages.;
DOI:10.1016/j.tet.2004.06.027

Reference yield:

: 350-03-8
methyl-3-pyridylketone

: 754215-70-8
methyl 3-acetyl-1-benzhydryl-α-(methylsulfanyl)-5-(trichloroacetyl)-1,4-dihydropyridine-4-acetate

Guidance literature:: Multi-step reaction with 2 steps

1.1: 55 percent / acetone / 168000 h / 20 °C

2.1: LDA / cyclohexane; tetrahydrofuran / 0.5 h / -78 °C

2.2: cyclohexane; tetrahydrofuran / -78 - -40 °C

2.3: 70 percent / Et₃N / cyclohexane; tetrahydrofuran / 12 h / 20 °C

With lithium diisopropyl amide; In tetrahydrofuran; cyclohexane; acetone;
DOI:10.1016/j.tet.2004.06.027

Reference yield:

: 776-74-9
Bromodiphenylmethane

: 754215-70-8
methyl 3-acetyl-1-benzhydryl-α-(methylsulfanyl)-5-(trichloroacetyl)-1,4-dihydropyridine-4-acetate

Guidance literature:: Multi-step reaction with 2 steps

1.1: 55 percent / acetone / 168000 h / 20 °C

2.1: LDA / cyclohexane; tetrahydrofuran / 0.5 h / -78 °C

2.2: cyclohexane; tetrahydrofuran / -78 - -40 °C

2.3: 70 percent / Et₃N / cyclohexane; tetrahydrofuran / 12 h / 20 °C

With lithium diisopropyl amide; In tetrahydrofuran; cyclohexane; acetone;
DOI:10.1016/j.tet.2004.06.027