((4S,4'S,5S,5'S)-2,2'-methylenebis(5-phenyl-4,5-dihydrooxazol-4,2-diyl))bis(methylene)diacetate

Base Information

Chemical Name:((4S,4'S,5S,5'S)-2,2'-methylenebis(5-phenyl-4,5-dihydrooxazol-4,2-diyl))bis(methylene)diacetate
CAS No.:1453106-65-4
Molecular Formula:C₂₅H₂₆N₂O₆
Molecular Weight:450.491
Hs Code.:

Synonyms:((4S,4'S,5S,5'S)-2,2'-methylenebis(5-phenyl-4,5-dihydrooxazol-4,2-diyl))bis(methylene)diacetate

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Chemical Property of ((4S,4'S,5S,5'S)-2,2'-methylenebis(5-phenyl-4,5-dihydrooxazol-4,2-diyl))bis(methylene)diacetate

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Technology Process of ((4S,4'S,5S,5'S)-2,2'-methylenebis(5-phenyl-4,5-dihydrooxazol-4,2-diyl))bis(methylene)diacetate

There total 4 articles about ((4S,4'S,5S,5'S)-2,2'-methylenebis(5-phenyl-4,5-dihydrooxazol-4,2-diyl))bis(methylene)diacetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

: 1453106-62-1
bis((4R,5S)-4-(bromomethyl)-5-phenyl-4,5-dihydrooxazol-2-yl)methane

: 127-08-2
potassium acetate

: 1453106-65-4
((4S,4'S,5S,5'S)-2,2'-methylenebis(5-phenyl-4,5-dihydrooxazol-4,2-diyl))bis(methylene)diacetate

Guidance literature:: In dimethyl sulfoxide; at 50 ℃; for 12h; Inert atmosphere; Schlenk technique; Sealed tube;
DOI:10.1002/ejoc.201300279

Reference yield:

: 10344-69-1
diethyl malonoimidate dihydrochloride

: 1453106-65-4
((4S,4'S,5S,5'S)-2,2'-methylenebis(5-phenyl-4,5-dihydrooxazol-4,2-diyl))bis(methylene)diacetate

Guidance literature:: Multi-step reaction with 3 steps

1: dichloromethane / 18 h / Inert atmosphere; Schlenk technique; Reflux

2: carbon tetrabromide; triphenylphosphine / dichloromethane / 16 h / 20 °C / Inert atmosphere; Schlenk technique

3: dimethyl sulfoxide / 12 h / 50 °C / Inert atmosphere; Schlenk technique; Sealed tube

With carbon tetrabromide; triphenylphosphine; In dichloromethane; dimethyl sulfoxide;
DOI:10.1002/ejoc.201300279

Reference yield:

: 133463-87-3
(-)-(4S,4'S,5S,5'S)-4,4',5,5'-Tetrahydro-2,2'-methylene-5,5'-diphenylbis-4,4'-di(methanol)

: 1453106-65-4
((4S,4'S,5S,5'S)-2,2'-methylenebis(5-phenyl-4,5-dihydrooxazol-4,2-diyl))bis(methylene)diacetate

Guidance literature:: Multi-step reaction with 2 steps

1: carbon tetrabromide; triphenylphosphine / dichloromethane / 16 h / 20 °C / Inert atmosphere; Schlenk technique

2: dimethyl sulfoxide / 12 h / 50 °C / Inert atmosphere; Schlenk technique; Sealed tube

With carbon tetrabromide; triphenylphosphine; In dichloromethane; dimethyl sulfoxide;
DOI:10.1002/ejoc.201300279