5-bromo-3-[1-(2-chloro-3-fluoro-6-methoxyphenyl)-2-fluoro-2,2-bis(phenylsulfonyl)ethyl]-1H-pyrrolo[2,3-b]pyridine

Base Information

• Chemical Name: 5-bromo-3-[1-(2-chloro-3-fluoro-6-methoxyphenyl)-2-fluoro-2,2-bis(phenylsulfonyl)ethyl]-1H-pyrrolo[2,3-b]pyridine
• CAS No.: 1413875-90-7
• Molecular Formula: C₂₈H₂₀BrClF₂N₂O₅S₂
• Molecular Weight: 681.963
• Mol file: 1413875-90-7.mol

Synonyms:5-bromo-3-[1-(2-chloro-3-fluoro-6-methoxyphenyl)-2-fluoro-2,2-bis(phenylsulfonyl)ethyl]-1H-pyrrolo[2,3-b]pyridine

Chemical Property of 5-bromo-3-[1-(2-chloro-3-fluoro-6-methoxyphenyl)-2-fluoro-2,2-bis(phenylsulfonyl)ethyl]-1H-pyrrolo[2,3-b]pyridine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 5-bromo-3-[1-(2-chloro-3-fluoro-6-methoxyphenyl)-2-fluoro-2,2-bis(phenylsulfonyl)ethyl]-1H-pyrrolo[2,3-b]pyridine

There total 5 articles about 5-bromo-3-[1-(2-chloro-3-fluoro-6-methoxyphenyl)-2-fluoro-2,2-bis(phenylsulfonyl)ethyl]-1H-pyrrolo[2,3-b]pyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

1-fluoro-1,1-bis(phenylsulfonyl)methane (910650-82-7) + 5-bromo-3-[(2-chloro-3-fluoro-6-methoxyphenyl)-hydroxymethyl]-1H-pyrrolo[2,3-b]pyridine (1350322-49-4) → 5-bromo-3-[1-(2-chloro-3-fluoro-6-methoxyphenyl)-2-fluoro-2,2-bis(phenylsulfonyl)ethyl]-1H-pyrrolo[2,3-b]pyridine (1413875-90-7)

Guidance literature:

1-fluoro-1,1-bis(phenylsulfonyl)methane; With n-butyllithium; In tetrahydrofuran; hexane; at -78 ℃; for 0.5h;

5-bromo-3-[(2-chloro-3-fluoro-6-methoxyphenyl)-hydroxymethyl]-1H-pyrrolo[2,3-b]pyridine; With thionyl chloride; In tetrahydrofuran; hexane; at -78 - 20 ℃; for 1.5h;

Reference yield:

2-chloro-1-fluoro-4-methoxybenzene (202925-07-3) → 5-bromo-3-[1-(2-chloro-3-fluoro-6-methoxyphenyl)-2-fluoro-2,2-bis(phenylsulfonyl)ethyl]-1H-pyrrolo[2,3-b]pyridine (1413875-90-7)

Guidance literature:

Multi-step reaction with 3 steps

1.1: n-butyllithium / hexane; tert-butyl methyl ether / -78 - -60 °C

2.1: potassium hydroxide / methanol / 12 h / 20 °C

3.1: n-butyllithium / hexane; tetrahydrofuran / 0.5 h / -78 °C

3.2: 1.5 h / -78 - 20 °C

With n-butyllithium; potassium hydroxide; In tetrahydrofuran; methanol; hexane; tert-butyl methyl ether;

Reference yield:

2-chloro-3-fluoro-6-methoxy-benzaldehyde (1263378-40-0) → 5-bromo-3-[1-(2-chloro-3-fluoro-6-methoxyphenyl)-2-fluoro-2,2-bis(phenylsulfonyl)ethyl]-1H-pyrrolo[2,3-b]pyridine (1413875-90-7)

Guidance literature:

Multi-step reaction with 2 steps

1.1: potassium hydroxide / methanol / 12 h / 20 °C

2.1: n-butyllithium / hexane; tetrahydrofuran / 0.5 h / -78 °C

2.2: 1.5 h / -78 - 20 °C

With n-butyllithium; potassium hydroxide; In tetrahydrofuran; methanol; hexane;

upstream raw materials:

5-bromo-1H-pyrrolo[2,3-b]pyridine

2-chloro-3,6-difluorobenzaldehyde

2-chloro-1-fluoro-4-methoxybenzene

1-fluoro-1,1-bis(phenylsulfonyl)methane

Downstream raw materials:

trans-4-(4-{3-[(1S)-1-(2-chloro-3-fluoro-6-methoxyphenyl)-2-fluoroethyl]-1H-pyrrolo[2,3-b]pyridin-5-yl}-1H-pyrazol-1-yl)cyclohexanol

trans-4-(4-{3-[(1R)-1-(2-chloro-3-fluoro-6-methoxyphenyl)-2-fluoroethyl]-1H-pyrrolo[2,3-b]pyridin-5-yl}-1H-pyrazol-1-yl)cyclohexanol

C₃₁H₃₉ClF₂N₄O₂Si

trans-4-(4-{3-[-1-(2-chloro-3-fluoro-6-methoxyphenyl)-2-fluoroethyl]-1H-pyrrolo[2,3-b]pyridin-5-yl}-1H-pyrazol-1-yl)cyclohexanol