(4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)methanol

Base Information

• Chemical Name: (4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)methanol
• CAS No.: 302348-51-2
• Molecular Formula: C13H19 B O3
• Molecular Weight: 234.103
• Hs Code.: 2934999090
• Mol file: 302348-51-2.mol

Synonyms:2-[4-(Hydroxymethyl)phenyl]-4,4,5,5-tetramethyl-1,3,2-dioxaborolane

Chemical Property of (4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)methanol

Chemical Property:

• Vapor Pressure: 1.33E-05mmHg at 25°C
• Melting Point: 74-80℃
• Refractive Index: 1.512
• Boiling Point: 353.3°Cat760mmHg
• PKA: 14.29±0.10(Predicted)
• Flash Point: 167.5°C
• PSA: 38.69000
• Density: 1.07g/cm³
• LogP: 1.47810
• Storage Temp.: 2-8°C
• Water Solubility.: Insoluble in water.

Purity/Quality:

98% ^*data from raw suppliers

4-HydroxyMethylphenylboronic acid pinacol ester ^*data from reagent suppliers

Safty Information:

• Hazard Codes: 36/37/38
• Safety Statements: 26-37

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

• Uses: 4-(Hydroxymethyl)benzeneboronic acid pinacol ester is used as pharmaceutical intermediate.

Technology Process of (4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)methanol

There total 13 articles about (4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)methanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

4-bromobenzenemethanol (873-75-6) + bis(pinacol)diborane (73183-34-3) → (4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)methanol (302348-51-2)

Guidance literature:

With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium acetate; In 1,4-dioxane; at 80 ℃; for 16h;

Reference yield: 96.0%

para-Chlorobenzyl alcohol (873-76-7) + bis(pinacol)diborane (73183-34-3) → (4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)methanol (302348-51-2)

Guidance literature:

With potassium phosphate tribasic heptahydrate; chloro(2-dicyclohexylphosphino-2’,4’,6’-triisopropyl-1,1‘-biphenyl)[2-(2’-amino-1,1‘-biphenyl’)]palladium(II); XPhos; In ethanol; at 20 ℃; for 2h;

DOI:10.1039/c8ra01381k

Reference yield: 96.0%

→ (4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)methanol (302348-51-2)

Guidance literature:

With potassium phosphate tribasic heptahydrate; chloro(2-dicyclohexylphosphino-2′,4′,6′-triisopropyl-1,1′-biphenyl)[2-(2-aminoethyl)phenyl]palladium(II) methyl-t-butyl ether adduct; XPhos; In ethanol; at 20 ℃; for 0.5h;

upstream raw materials:

4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzaldehyde

2,3-dimethyl-2,3-butane diol

4-formylphenylboronic acid,

2-[4'-(4'',4'',5'',5''-tetramethyl-1'',3'',2''-dioxaborolan-2''-yl)-benzyloxy]tetrahydrofuran

Downstream raw materials:

4-bromomethylphenylboronic acid pinacol ester

C₁₅H₁₉BCl₃NO₃

peroxy lucifer 1

(CH₃)4C₂O₂BC₆H₄CH₂OC(O)NHC₆H₃(NO₂)COOCH₂CHCH₂

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