diethyl 1-((S)-2-(4-methyl-2-oxo-2H-chromen-7-yloxy)propanamido)-1-phenylethylphosphonate

Base Information

Chemical Name:diethyl 1-((S)-2-(4-methyl-2-oxo-2H-chromen-7-yloxy)propanamido)-1-phenylethylphosphonate
CAS No.:1533457-26-9
Molecular Formula:C₂₅H₃₀NO₇P
Molecular Weight:487.489
Hs Code.:

Synonyms:diethyl 1-((S)-2-(4-methyl-2-oxo-2H-chromen-7-yloxy)propanamido)-1-phenylethylphosphonate

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Chemical Property of diethyl 1-((S)-2-(4-methyl-2-oxo-2H-chromen-7-yloxy)propanamido)-1-phenylethylphosphonate

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Technology Process of diethyl 1-((S)-2-(4-methyl-2-oxo-2H-chromen-7-yloxy)propanamido)-1-phenylethylphosphonate

There total 5 articles about diethyl 1-((S)-2-(4-methyl-2-oxo-2H-chromen-7-yloxy)propanamido)-1-phenylethylphosphonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

: 885126-83-0
(S)-2-(4-methyl-2-oxo-2H-chromen-7-yloxy)propanoic acid

: 64228-66-6,84044-06-4
(1-amino-1-phenyl-ethyl)-phosphonic acid diethyl ester

: 1533457-26-9
diethyl 1-((S)-2-(4-methyl-2-oxo-2H-chromen-7-yloxy)propanamido)-1-phenylethylphosphonate

Guidance literature:: With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dimethyl sulfoxide; at 20 ℃; Cooling with ice;
DOI:10.1007/s00044-013-0899-3

Reference yield:

: 90-33-5,79566-13-5
7-hydroxy-4-methyl-chromen-2-one

: 1533457-26-9
diethyl 1-((S)-2-(4-methyl-2-oxo-2H-chromen-7-yloxy)propanamido)-1-phenylethylphosphonate

Guidance literature:: Multi-step reaction with 2 steps

1: potassium carbonate / acetone / 13 h / 56 °C

2: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dimethyl sulfoxide / 20 °C / Cooling with ice

With potassium carbonate; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dimethyl sulfoxide; acetone;
DOI:10.1007/s00044-013-0899-3

Reference yield:

: 98-86-2
acetophenone

: 1533457-26-9
diethyl 1-((S)-2-(4-methyl-2-oxo-2H-chromen-7-yloxy)propanamido)-1-phenylethylphosphonate

Guidance literature:: Multi-step reaction with 3 steps

1.1: ammonium acetate / 6 h / Reflux

1.2: 3 h / 70 °C

2.1: hydrogenchloride / diethyl ether / 2 h / 0 °C

2.2: 0.5 h / 20 °C

3.1: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dimethyl sulfoxide / 20 °C / Cooling with ice

With hydrogenchloride; ammonium acetate; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In diethyl ether; dimethyl sulfoxide;
DOI:10.1007/s00044-013-0899-3