1-({4-[6-methyl-3-(trifluoromethyl)-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridin-1-yl]phenyl}methyl)-2-pyrrolidinone

Base Information

Chemical Name:1-({4-[6-methyl-3-(trifluoromethyl)-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridin-1-yl]phenyl}methyl)-2-pyrrolidinone
CAS No.:1022930-40-0
Molecular Formula:C₁₉H₂₁F₃N₄O
Molecular Weight:378.397
Hs Code.:

Synonyms:1-({4-[6-methyl-3-(trifluoromethyl)-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridin-1-yl]phenyl}methyl)-2-pyrrolidinone

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Chemical Property of 1-({4-[6-methyl-3-(trifluoromethyl)-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridin-1-yl]phenyl}methyl)-2-pyrrolidinone

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Technology Process of 1-({4-[6-methyl-3-(trifluoromethyl)-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridin-1-yl]phenyl}methyl)-2-pyrrolidinone

There total 5 articles about 1-({4-[6-methyl-3-(trifluoromethyl)-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridin-1-yl]phenyl}methyl)-2-pyrrolidinone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 40.0%

: 950785-27-0
1-[(4-iodophenyl)methyl]-2-pyrrolidinone

: 1022931-56-1
6-methyl-3-(trifluoromethyl)-4,5,6,7-tetrahydro-1H-pyrazolo-[3,4-c]pyridine

: 1022930-40-0
1-({4-[6-methyl-3-(trifluoromethyl)-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridin-1-yl]phenyl}methyl)-2-pyrrolidinone

Guidance literature:: With caesium carbonate; copper(I) oxide; dimethylaminoacetic acid; In dimethyl sulfoxide; at 190 ℃; for 0.5h; Microwave irradiation;

Reference yield:

: 647863-25-0
tert-butyl 3-oxo-4-(2,2,2-trifluoroacetyl)piperidine-1-carboxylate

: 1022930-40-0
1-({4-[6-methyl-3-(trifluoromethyl)-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridin-1-yl]phenyl}methyl)-2-pyrrolidinone

Guidance literature:: Multi-step reaction with 3 steps

1: hydrazine hydrate / ethanol / 24 h / 50 °C

2: lithium aluminium tetrahydride / tetrahydrofuran / 17 h / 58 °C / Inert atmosphere

3: copper(I) oxide; dimethylaminoacetic acid; caesium carbonate / dimethyl sulfoxide / 16 h / 130 °C

With copper(I) oxide; lithium aluminium tetrahydride; dimethylaminoacetic acid; caesium carbonate; hydrazine hydrate; In tetrahydrofuran; ethanol; dimethyl sulfoxide;
DOI:10.1021/jm100679e

Reference yield:

: 733757-89-6
6-tert-butoxycarbonyl-3-(trifluoromethyl)-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine

: 1022930-40-0
1-({4-[6-methyl-3-(trifluoromethyl)-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridin-1-yl]phenyl}methyl)-2-pyrrolidinone

Guidance literature:: Multi-step reaction with 2 steps

1: lithium aluminium tetrahydride / tetrahydrofuran / 17 h / 58 °C / Inert atmosphere

2: copper(I) oxide; dimethylaminoacetic acid; caesium carbonate / dimethyl sulfoxide / 16 h / 130 °C

With copper(I) oxide; lithium aluminium tetrahydride; dimethylaminoacetic acid; caesium carbonate; In tetrahydrofuran; dimethyl sulfoxide;
DOI:10.1021/jm100679e