(4S)-3-((2S)-3,3-difluoro-2-phenyl-3-(trimethylsilyl)propanoyl)-4-phenyloxazolidin-2-one

Base Information

Chemical Name:(4S)-3-((2S)-3,3-difluoro-2-phenyl-3-(trimethylsilyl)propanoyl)-4-phenyloxazolidin-2-one
CAS No.:1598387-28-0
Molecular Formula:C₂₁H₂₃F₂NO₃Si
Molecular Weight:403.501
Hs Code.:

Synonyms:(4S)-3-((2S)-3,3-difluoro-2-phenyl-3-(trimethylsilyl)propanoyl)-4-phenyloxazolidin-2-one

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Chemical Property of (4S)-3-((2S)-3,3-difluoro-2-phenyl-3-(trimethylsilyl)propanoyl)-4-phenyloxazolidin-2-one

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Technology Process of (4S)-3-((2S)-3,3-difluoro-2-phenyl-3-(trimethylsilyl)propanoyl)-4-phenyloxazolidin-2-one

There total 3 articles about (4S)-3-((2S)-3,3-difluoro-2-phenyl-3-(trimethylsilyl)propanoyl)-4-phenyloxazolidin-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.0%

: 1441150-48-6
(S)-4-phenyl-3-(2-phenylacetyl)oxazolidin-2-one

: 81290-20-2
(trifluoromethyl)trimethylsilane

: 1598387-28-0
(4S)-3-((2S)-3,3-difluoro-2-phenyl-3-(trimethylsilyl)propanoyl)-4-phenyloxazolidin-2-one

Guidance literature:: (S)-4-phenyl-3-(2-phenylacetyl)oxazolidin-2-one; With lithium hexamethyldisilazane; In tetrahydrofuran; at -78 ℃; for 1h; Inert atmosphere;

With methyllithium; In tetrahydrofuran; at -78 ℃; for 0.166667h; Inert atmosphere;

(trifluoromethyl)trimethylsilane; In tetrahydrofuran; at -78 ℃; Inert atmosphere;
DOI:10.1021/acs.orglett.0c03508

Reference yield:

: 99395-88-7,7480-32-2
(S)-4-phenyl-2-oxazolidinone

: 1598387-28-0
(4S)-3-((2S)-3,3-difluoro-2-phenyl-3-(trimethylsilyl)propanoyl)-4-phenyloxazolidin-2-one

Guidance literature:: Multi-step reaction with 2 steps

1.1: n-butyllithium / tetrahydrofuran / Inert atmosphere

2.1: lithium hexamethyldisilazane / tetrahydrofuran / 1 h / -78 °C / Inert atmosphere

2.2: 0.17 h / -78 °C / Inert atmosphere

2.3: -78 °C / Inert atmosphere

With n-butyllithium; lithium hexamethyldisilazane; In tetrahydrofuran;
DOI:10.1021/acs.orglett.0c03508

Reference yield:

: 103-80-0
phenylacetyl chloride

: 1598387-28-0
(4S)-3-((2S)-3,3-difluoro-2-phenyl-3-(trimethylsilyl)propanoyl)-4-phenyloxazolidin-2-one

Guidance literature:: Multi-step reaction with 2 steps

1.1: n-butyllithium / tetrahydrofuran / Inert atmosphere

2.1: lithium hexamethyldisilazane / tetrahydrofuran / 1 h / -78 °C / Inert atmosphere

2.2: 0.17 h / -78 °C / Inert atmosphere

2.3: -78 °C / Inert atmosphere

With n-butyllithium; lithium hexamethyldisilazane; In tetrahydrofuran;
DOI:10.1021/acs.orglett.0c03508