2,2-dimethyl-propionic acid 1-benzyl-3-hydroxy-piperidin-2-ylmethyl ester

Base Information

Chemical Name:2,2-dimethyl-propionic acid 1-benzyl-3-hydroxy-piperidin-2-ylmethyl ester
CAS No.:817196-20-6
Molecular Formula:C₁₈H₂₇NO₃
Molecular Weight:305.417
Hs Code.:

Synonyms:2,2-dimethyl-propionic acid 1-benzyl-3-hydroxy-piperidin-2-ylmethyl ester

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Chemical Property of 2,2-dimethyl-propionic acid 1-benzyl-3-hydroxy-piperidin-2-ylmethyl ester

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Technology Process of 2,2-dimethyl-propionic acid 1-benzyl-3-hydroxy-piperidin-2-ylmethyl ester

There total 10 articles about 2,2-dimethyl-propionic acid 1-benzyl-3-hydroxy-piperidin-2-ylmethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

: 817196-16-0
rac-(1-benzyl-3-oxopiperidin-2-yl)methyl 2,2-dimethylpropanoate

: 817196-20-6
2,2-dimethyl-propionic acid 1-benzyl-3-hydroxy-piperidin-2-ylmethyl ester

Guidance literature:: With sodium tetrahydroborate; In ethanol; at -15 ℃;
DOI:10.1002/hlca.200490236

Reference yield:

: 14173-30-9
3-hydroxy-2-hydroxymethylpyridine hydrochloride

: 817196-20-6
2,2-dimethyl-propionic acid 1-benzyl-3-hydroxy-piperidin-2-ylmethyl ester

Guidance literature:: Multi-step reaction with 5 steps

1: H₂ / Rh/Alox / H₂O / 18 h / 35 °C / 45003.6 Torr / pH 3.0

2: 5.25 g / Na₂CO₃ / H₂O; ethanol / 0.5 h / Heating

3: pyridine / 48 h / -20 °C

4: 96 percent / (COCl)2; DMSO; Et₃N / CH₂Cl₂ / 0.83 h / -60 - 20 °C

5: 96 percent / NaBH₄ / ethanol / -15 °C

With pyridine; sodium tetrahydroborate; oxalyl dichloride; hydrogen; sodium carbonate; dimethyl sulfoxide; triethylamine; Rh/Al₂O₃; In ethanol; dichloromethane; water; 4: Swern oxidation;
DOI:10.1002/hlca.200490236

Reference yield:

: 3282-30-2
pivaloyl chloride

: 817196-20-6
2,2-dimethyl-propionic acid 1-benzyl-3-hydroxy-piperidin-2-ylmethyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: pyridine / 48 h / -20 °C

2: 96 percent / (COCl)2; DMSO; Et₃N / CH₂Cl₂ / 0.83 h / -60 - 20 °C

3: 96 percent / NaBH₄ / ethanol / -15 °C

With pyridine; sodium tetrahydroborate; oxalyl dichloride; dimethyl sulfoxide; triethylamine; In ethanol; dichloromethane; 2: Swern oxidation;
DOI:10.1002/hlca.200490236