[5-(1-benzenesulfonyl-5-chloro-1H-pyrrolo[2,3-b]pyridin-3-ylmethyl)-4-chlorothiazol-2-yl]carbamic acid tert-butyl ester

Base Information

Chemical Name:[5-(1-benzenesulfonyl-5-chloro-1H-pyrrolo[2,3-b]pyridin-3-ylmethyl)-4-chlorothiazol-2-yl]carbamic acid tert-butyl ester
CAS No.:1029052-68-3
Molecular Formula:C₂₂H₂₀Cl₂N₄O₄S₂
Molecular Weight:539.463
Hs Code.:

Synonyms:[5-(1-benzenesulfonyl-5-chloro-1H-pyrrolo[2,3-b]pyridin-3-ylmethyl)-4-chlorothiazol-2-yl]carbamic acid tert-butyl ester

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Chemical Property of [5-(1-benzenesulfonyl-5-chloro-1H-pyrrolo[2,3-b]pyridin-3-ylmethyl)-4-chlorothiazol-2-yl]carbamic acid tert-butyl ester

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Purity/Quality:: 99% ^*data from raw suppliers

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Technology Process of [5-(1-benzenesulfonyl-5-chloro-1H-pyrrolo[2,3-b]pyridin-3-ylmethyl)-4-chlorothiazol-2-yl]carbamic acid tert-butyl ester

There total 5 articles about [5-(1-benzenesulfonyl-5-chloro-1H-pyrrolo[2,3-b]pyridin-3-ylmethyl)-4-chlorothiazol-2-yl]carbamic acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 24424-99-5
di-tert-butyl dicarbonate

: 1029052-68-3
[5-(1-benzenesulfonyl-5-chloro-1H-pyrrolo[2,3-b]pyridin-3-ylmethyl)-4-chlorothiazol-2-yl]carbamic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 3 steps

1.1: dmap / tetrahydrofuran / 2 h / 58 °C

2.1: isopropylmagnesium chloride / tetrahydrofuran / 0.67 h / -45 - -25 °C / Inert atmosphere

2.2: 2 h / -65 - 20 °C / Inert atmosphere

3.1: triethylsilane; trifluoroacetic acid / dichloromethane / 3 h / 20 °C

With triethylsilane; dmap; isopropylmagnesium chloride; trifluoroacetic acid; In tetrahydrofuran; dichloromethane;

Reference yield:

: 388594-31-8
(4-chloro-5-formylthiazol-2-yl)carbamic acid tert-butyl ester

: 1029052-68-3
[5-(1-benzenesulfonyl-5-chloro-1H-pyrrolo[2,3-b]pyridin-3-ylmethyl)-4-chlorothiazol-2-yl]carbamic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 2 steps

1.1: isopropylmagnesium chloride / tetrahydrofuran / 0.67 h / -45 - -25 °C

1.2: 2 h / -78 - 20 °C

2.1: triethylsilane; trifluoroacetic acid / dichloromethane / 3 h / 20 °C

With triethylsilane; isopropylmagnesium chloride; trifluoroacetic acid; In tetrahydrofuran; dichloromethane;

Reference yield:

: 866546-07-8
5-chloro-1H-pyrrolo[2,3-b]pyridine

: 1029052-68-3
[5-(1-benzenesulfonyl-5-chloro-1H-pyrrolo[2,3-b]pyridin-3-ylmethyl)-4-chlorothiazol-2-yl]carbamic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 4 steps

1.1: Iodine monochloride; pyridine / dichloromethane / 2.33 h / 20 °C / Inert atmosphere

2.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 15 h / 0 - 20 °C

3.1: isopropylmagnesium chloride / tetrahydrofuran / 0.67 h / -45 - -25 °C / Inert atmosphere

3.2: 2 h / -65 - 20 °C / Inert atmosphere

4.1: triethylsilane; trifluoroacetic acid / dichloromethane / 3 h / 20 °C

With pyridine; triethylsilane; isopropylmagnesium chloride; Iodine monochloride; sodium hydride; trifluoroacetic acid; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide; mineral oil;