(R)-2-(5-cyano-6-(quinolin-6-ylamino)pyrazin-2-ylamino)-3-phenylpropanamide

Base Information

Chemical Name:(R)-2-(5-cyano-6-(quinolin-6-ylamino)pyrazin-2-ylamino)-3-phenylpropanamide
CAS No.:1438423-99-4
Molecular Formula:C₂₃H₁₉N₇O
Molecular Weight:409.45
Hs Code.:

Synonyms:(R)-2-(5-cyano-6-(quinolin-6-ylamino)pyrazin-2-ylamino)-3-phenylpropanamide

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Chemical Property of (R)-2-(5-cyano-6-(quinolin-6-ylamino)pyrazin-2-ylamino)-3-phenylpropanamide

Chemical Property:

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Technology Process of (R)-2-(5-cyano-6-(quinolin-6-ylamino)pyrazin-2-ylamino)-3-phenylpropanamide

There total 3 articles about (R)-2-(5-cyano-6-(quinolin-6-ylamino)pyrazin-2-ylamino)-3-phenylpropanamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 580-15-4
6-aminoquinoline

: 1438423-98-3
(R)-2-(6-chloro-5-cyanopyrazin-2-ylamino)-3-phenylpropanamide

: 1438423-99-4
(R)-2-(5-cyano-6-(quinolin-6-ylamino)pyrazin-2-ylamino)-3-phenylpropanamide

Guidance literature:: With palladium diacetate; potassium carbonate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; In 1,4-dioxane; at 110 ℃; for 20h; Inert atmosphere;

Reference yield:

: 5241-58-7,5241-59-8,17193-31-6,60058-39-1
D-Phenylalaninamide

: 1438423-99-4
(R)-2-(5-cyano-6-(quinolin-6-ylamino)pyrazin-2-ylamino)-3-phenylpropanamide

Guidance literature:: Multi-step reaction with 2 steps

1: N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 20 h / 20 °C

2: 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; palladium diacetate; potassium carbonate / 1,4-dioxane / 20 h / 110 °C / Inert atmosphere

With palladium diacetate; potassium carbonate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; N-ethyl-N,N-diisopropylamine; In 1,4-dioxane; N,N-dimethyl-formamide;

Reference yield:

: 313339-92-3
3,5-dichloro-pyrazine-2-carbonitrile

: 1438423-99-4
(R)-2-(5-cyano-6-(quinolin-6-ylamino)pyrazin-2-ylamino)-3-phenylpropanamide

Guidance literature:: Multi-step reaction with 2 steps

1: N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 20 h / 20 °C

2: 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; palladium diacetate; potassium carbonate / 1,4-dioxane / 20 h / 110 °C / Inert atmosphere

With palladium diacetate; potassium carbonate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; N-ethyl-N,N-diisopropylamine; In 1,4-dioxane; N,N-dimethyl-formamide;