ethyl 4-(3-(benzyloxycarbonylamino)-2-methylphenyl)-7-((2-(trimethylsilyl)ethoxy)carbonylamino)-9H-pyrido[3,4-b]indole-1-carboxylate

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Chemical Name:ethyl 4-(3-(benzyloxycarbonylamino)-2-methylphenyl)-7-((2-(trimethylsilyl)ethoxy)carbonylamino)-9H-pyrido[3,4-b]indole-1-carboxylate
CAS No.:1352835-68-7
Molecular Formula:C₃₅H₃₈N₄O₆Si
Molecular Weight:638.795
Hs Code.:

Synonyms:ethyl 4-(3-(benzyloxycarbonylamino)-2-methylphenyl)-7-((2-(trimethylsilyl)ethoxy)carbonylamino)-9H-pyrido[3,4-b]indole-1-carboxylate

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Chemical Property of ethyl 4-(3-(benzyloxycarbonylamino)-2-methylphenyl)-7-((2-(trimethylsilyl)ethoxy)carbonylamino)-9H-pyrido[3,4-b]indole-1-carboxylate

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Technology Process of ethyl 4-(3-(benzyloxycarbonylamino)-2-methylphenyl)-7-((2-(trimethylsilyl)ethoxy)carbonylamino)-9H-pyrido[3,4-b]indole-1-carboxylate

There total 10 articles about ethyl 4-(3-(benzyloxycarbonylamino)-2-methylphenyl)-7-((2-(trimethylsilyl)ethoxy)carbonylamino)-9H-pyrido[3,4-b]indole-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 20.57%

: 924-44-7
glyoxylic acid ethyl ester

: 1352835-67-6
C₃₁H₃₈N₄O₄Si

: 1352835-68-7
ethyl 4-(3-(benzyloxycarbonylamino)-2-methylphenyl)-7-((2-(trimethylsilyl)ethoxy)carbonylamino)-9H-pyrido[3,4-b]indole-1-carboxylate

Guidance literature:: glyoxylic acid ethyl ester; C₃₁H₃₈N₄O₄Si; With hydrogenchloride; In 1,4-dioxane; toluene; at 20 ℃; for 16h; Inert atmosphere;

palladium 10% on activated carbon; In para-xylene; at 115 ℃; for 6.5h;

Reference yield:

: 5318-27-4
6-amino-1H-indole

: 1352835-68-7
ethyl 4-(3-(benzyloxycarbonylamino)-2-methylphenyl)-7-((2-(trimethylsilyl)ethoxy)carbonylamino)-9H-pyrido[3,4-b]indole-1-carboxylate

Guidance literature:: Multi-step reaction with 4 steps

1.1: N-ethyl-N,N-diisopropylamine / 1,4-dioxane / Inert atmosphere

2.1: 6.5 h / 115 °C

3.1: zinc; ammonium chloride / tetrahydrofuran; methanol / 5.25 h / Inert atmosphere

4.1: hydrogenchloride / toluene; 1,4-dioxane / 16 h / 20 °C / Inert atmosphere

4.2: 6.5 h / 115 °C

With hydrogenchloride; ammonium chloride; N-ethyl-N,N-diisopropylamine; zinc; In tetrahydrofuran; 1,4-dioxane; methanol; toluene;

Reference yield:

: 78269-85-9
carbonic acid 2,5-dioxo-pyrrolidin-1-yl ester 2-(trimethylsilanyl)-ethyl ester

: 1352835-68-7
ethyl 4-(3-(benzyloxycarbonylamino)-2-methylphenyl)-7-((2-(trimethylsilyl)ethoxy)carbonylamino)-9H-pyrido[3,4-b]indole-1-carboxylate

Guidance literature:: Multi-step reaction with 4 steps

1.1: N-ethyl-N,N-diisopropylamine / 1,4-dioxane / Inert atmosphere

2.1: 6.5 h / 115 °C

3.1: zinc; ammonium chloride / tetrahydrofuran; methanol / 5.25 h / Inert atmosphere

4.1: hydrogenchloride / toluene; 1,4-dioxane / 16 h / 20 °C / Inert atmosphere

4.2: 6.5 h / 115 °C

With hydrogenchloride; ammonium chloride; N-ethyl-N,N-diisopropylamine; zinc; In tetrahydrofuran; 1,4-dioxane; methanol; toluene;