prop-1-en-2-yl (5-(7-chloro-2-methyl-1,6-naphthyridin-3-yl)-2-fluoro-4-methylphenyl)carbamate

Base Information

Chemical Name:prop-1-en-2-yl (5-(7-chloro-2-methyl-1,6-naphthyridin-3-yl)-2-fluoro-4-methylphenyl)carbamate
CAS No.:1455038-10-4
Molecular Formula:C₂₀H₁₇ClFN₃O₂
Molecular Weight:385.825
Hs Code.:

Synonyms:prop-1-en-2-yl (5-(7-chloro-2-methyl-1,6-naphthyridin-3-yl)-2-fluoro-4-methylphenyl)carbamate

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Chemical Property of prop-1-en-2-yl (5-(7-chloro-2-methyl-1,6-naphthyridin-3-yl)-2-fluoro-4-methylphenyl)carbamate

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Technology Process of prop-1-en-2-yl (5-(7-chloro-2-methyl-1,6-naphthyridin-3-yl)-2-fluoro-4-methylphenyl)carbamate

There total 12 articles about prop-1-en-2-yl (5-(7-chloro-2-methyl-1,6-naphthyridin-3-yl)-2-fluoro-4-methylphenyl)carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 57933-83-2
Isopropenyl chloroformate

: 1455035-98-9
5-(7-chloro-2-methyl[1,6]naphthyridin-3-yl)-2-fluoro-4-methylaniline

: 1455038-10-4
prop-1-en-2-yl (5-(7-chloro-2-methyl-1,6-naphthyridin-3-yl)-2-fluoro-4-methylphenyl)carbamate

Guidance literature:: With sodium hydrogencarbonate; In ethyl acetate; at 20 ℃;

Reference yield:

: 40296-46-6
ethyl 4,6-dichloronicotinate

: 1455038-10-4
prop-1-en-2-yl (5-(7-chloro-2-methyl-1,6-naphthyridin-3-yl)-2-fluoro-4-methylphenyl)carbamate

Guidance literature:: Multi-step reaction with 8 steps

1: triethylamine / dimethyl sulfoxide / 20 °C

2: trifluoroacetic acid / 50 °C

3: lithium aluminium tetrahydride / tetrahydrofuran / 0 - 20 °C / Inert atmosphere

4: manganese(IV) oxide / dichloromethane / 20 °C

5: potassium hydroxide / tetrahydrofuran / 1 h / 20 °C

6: pyridine / dichloromethane / 2 h / 0 °C / Inert atmosphere

7: potassium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,4-dioxane; water / 1 h / 60 °C / Inert atmosphere

8: sodium hydrogencarbonate / ethyl acetate / 20 °C

With pyridine; manganese(IV) oxide; lithium aluminium tetrahydride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium hydrogencarbonate; potassium carbonate; triethylamine; trifluoroacetic acid; potassium hydroxide; In tetrahydrofuran; 1,4-dioxane; dichloromethane; water; dimethyl sulfoxide; ethyl acetate; 8: |Schotten-Baumann Reaction;

Reference yield:

: 1001756-21-3
4-amino-6-chloropyridine-3-carboxaldehyde

: 1455038-10-4
prop-1-en-2-yl (5-(7-chloro-2-methyl-1,6-naphthyridin-3-yl)-2-fluoro-4-methylphenyl)carbamate

Guidance literature:: Multi-step reaction with 4 steps

1: potassium hydroxide / tetrahydrofuran / 1 h / 20 °C

2: pyridine / dichloromethane / 2 h / 0 °C / Inert atmosphere

3: potassium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,4-dioxane; water / 1 h / 60 °C / Inert atmosphere

4: sodium hydrogencarbonate / ethyl acetate / 20 °C

With pyridine; tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium hydrogencarbonate; potassium carbonate; potassium hydroxide; In tetrahydrofuran; 1,4-dioxane; dichloromethane; water; ethyl acetate; 4: |Schotten-Baumann Reaction;