tert-butyl 3-bromo-8-(methylthio)imidazo[1,2-a]pyrazin-6-yl(cyclohexylmethyl)carbamate

Base Information

Chemical Name:tert-butyl 3-bromo-8-(methylthio)imidazo[1,2-a]pyrazin-6-yl(cyclohexylmethyl)carbamate
CAS No.:1263425-51-9
Molecular Formula:C₁₉H₂₇BrN₄O₂S
Molecular Weight:455.419
Hs Code.:

Synonyms:tert-butyl 3-bromo-8-(methylthio)imidazo[1,2-a]pyrazin-6-yl(cyclohexylmethyl)carbamate

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Chemical Property of tert-butyl 3-bromo-8-(methylthio)imidazo[1,2-a]pyrazin-6-yl(cyclohexylmethyl)carbamate

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Technology Process of tert-butyl 3-bromo-8-(methylthio)imidazo[1,2-a]pyrazin-6-yl(cyclohexylmethyl)carbamate

There total 6 articles about tert-butyl 3-bromo-8-(methylthio)imidazo[1,2-a]pyrazin-6-yl(cyclohexylmethyl)carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.0%

: 1263425-50-8
tert-butyl 3-bromo-8-(methylthio)imidazo[1,2-a]pyrazin-6-ylcarbamate

: 2550-36-9
Cyclohexylmethyl bromide

: 1263425-51-9
tert-butyl 3-bromo-8-(methylthio)imidazo[1,2-a]pyrazin-6-yl(cyclohexylmethyl)carbamate

Guidance literature:: With sodium hydride; potassium iodide; In 2,4-dichlorophenoxyacetic acid dimethylamine; mineral oil; at 20 ℃; for 6h;

Reference yield:

: 887475-71-0
6-bromo-8-methylsulfanyl-imidazo[1,2-a]pyrazine

: 1263425-51-9
tert-butyl 3-bromo-8-(methylthio)imidazo[1,2-a]pyrazin-6-yl(cyclohexylmethyl)carbamate

Guidance literature:: Multi-step reaction with 6 steps

1: 1,1'-bis-(diphenylphosphino)ferrocene; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾ / 2,4-dichlorophenoxyacetic acid dimethylamine / 5 h / 120 °C

2: N-Bromosuccinimide / ethanol / 4 h / 20 °C

3: chloro-trimethyl-silane / 36 h / 80 °C

4: water; lithium hydroxide / tetrahydrofuran / 0.33 h / 20 °C

5: triethylamine; diphenyl phosphoryl azide / 4 h / Reflux

6: potassium iodide; sodium hydride / 2,4-dichlorophenoxyacetic acid dimethylamine; mineral oil / 6 h / 20 °C

With N-Bromosuccinimide; chloro-trimethyl-silane; diphenyl phosphoryl azide; water; sodium hydride; triethylamine; potassium iodide; lithium hydroxide; 1,1'-bis-(diphenylphosphino)ferrocene; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; In tetrahydrofuran; ethanol; 2,4-dichlorophenoxyacetic acid dimethylamine; mineral oil;

Reference yield:

: 1263425-49-5
3-bromo-8-(methylthio)imidazo[1,2-a]pyrazine-6-carboxylic acid

: 1263425-51-9
tert-butyl 3-bromo-8-(methylthio)imidazo[1,2-a]pyrazin-6-yl(cyclohexylmethyl)carbamate

Guidance literature:: Multi-step reaction with 2 steps

1: triethylamine; diphenyl phosphoryl azide / 4 h / Reflux

2: potassium iodide; sodium hydride / 2,4-dichlorophenoxyacetic acid dimethylamine; mineral oil / 6 h / 20 °C

With diphenyl phosphoryl azide; sodium hydride; triethylamine; potassium iodide; In 2,4-dichlorophenoxyacetic acid dimethylamine; mineral oil;