ethyl 1-(4'-(2-(benzyloxycarbonyl)-3-(methylamino)but-2-enoyl)biphenyl-4-yl)cyclopropanecarboxylate

Base Information

Chemical Name:ethyl 1-(4'-(2-(benzyloxycarbonyl)-3-(methylamino)but-2-enoyl)biphenyl-4-yl)cyclopropanecarboxylate
CAS No.:1380650-61-2
Molecular Formula:C₃₁H₃₁NO₅
Molecular Weight:497.591
Hs Code.:

Synonyms:ethyl 1-(4'-(2-(benzyloxycarbonyl)-3-(methylamino)but-2-enoyl)biphenyl-4-yl)cyclopropanecarboxylate

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Chemical Property of ethyl 1-(4'-(2-(benzyloxycarbonyl)-3-(methylamino)but-2-enoyl)biphenyl-4-yl)cyclopropanecarboxylate

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Technology Process of ethyl 1-(4'-(2-(benzyloxycarbonyl)-3-(methylamino)but-2-enoyl)biphenyl-4-yl)cyclopropanecarboxylate

There total 6 articles about ethyl 1-(4'-(2-(benzyloxycarbonyl)-3-(methylamino)but-2-enoyl)biphenyl-4-yl)cyclopropanecarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 61312-70-7
3-methylamino-but-2-enoic acid benzyl ester

: C₁₉H₁₇ClO₃

: 1380650-61-2
ethyl 1-(4'-(2-(benzyloxycarbonyl)-3-(methylamino)but-2-enoyl)biphenyl-4-yl)cyclopropanecarboxylate

Guidance literature:: With pyridine; In tetrahydrofuran; at 50 ℃; for 2h;

Reference yield:

: 1380650-58-7
4'-(1-(ethoxycarbonyl)cyclopropyl)biphenyl-4-carboxylic acid

: 864851-43-4
C₁₁H₁₃NO₂

: 1380650-61-2
ethyl 1-(4'-(2-(benzyloxycarbonyl)-3-(methylamino)but-2-enoyl)biphenyl-4-yl)cyclopropanecarboxylate

Guidance literature:: 4'-(1-(ethoxycarbonyl)cyclopropyl)biphenyl-4-carboxylic acid; With thionyl chloride; In 1,2-dichloro-ethane; N,N-dimethyl-formamide; at 80 ℃; for 1.5h;

C₁₁H₁₃NO₂; With pyridine; In tetrahydrofuran; at 50 ℃; for 2h;

Reference yield:

: 31603-77-7
4-biphenylacetonitrile

: 1380650-61-2
ethyl 1-(4'-(2-(benzyloxycarbonyl)-3-(methylamino)but-2-enoyl)biphenyl-4-yl)cyclopropanecarboxylate

Guidance literature:: Multi-step reaction with 6 steps

1.1: potassium hydroxide; tetrabutylammomium bromide / toluene; water / 48 h / 20 - 80 °C

2.1: potassium hydroxide; water / ethylene glycol / 3 h / 170 °C

3.1: sulfuric acid / 16 h / Reflux

4.1: aluminum (III) chloride / dichloromethane / 2 h / 20 °C

5.1: sodium hydroxide; bromine; water / 1,4-dioxane / 0.5 h / 10 - 20 °C

6.1: thionyl chloride / N,N-dimethyl-formamide; 1,2-dichloro-ethane / 1.5 h / 80 °C

6.2: 2 h / 50 °C

With aluminum (III) chloride; thionyl chloride; sulfuric acid; tetrabutylammomium bromide; water; bromine; potassium hydroxide; sodium hydroxide; In 1,4-dioxane; dichloromethane; water; ethylene glycol; 1,2-dichloro-ethane; N,N-dimethyl-formamide; toluene;