(3aS)-2,3,3a,4-tetrahydro-1H-5-oxa-9b-aza-cyclopenta[a]naphthalene

Base Information

• Chemical Name: (3aS)-2,3,3a,4-tetrahydro-1H-5-oxa-9b-aza-cyclopenta[a]naphthalene
• CAS No.: 896462-42-3
• Molecular Formula: C₁₁H₁₃NO
• Molecular Weight: 175.23
• Mol file: 896462-42-3.mol

Synonyms:(3aS)-2,3,3a,4-tetrahydro-1H-5-oxa-9b-aza-cyclopenta[a]naphthalene

Chemical Property of (3aS)-2,3,3a,4-tetrahydro-1H-5-oxa-9b-aza-cyclopenta[a]naphthalene

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (3aS)-2,3,3a,4-tetrahydro-1H-5-oxa-9b-aza-cyclopenta[a]naphthalene

There total 2 articles about (3aS)-2,3,3a,4-tetrahydro-1H-5-oxa-9b-aza-cyclopenta[a]naphthalene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

1-Bromo-2-iodobenzene (583-55-1) + (S)-1-Pyrrolidin-2-yl-methanol (23356-96-9) → (3aS)-2,3,3a,4-tetrahydro-1H-5-oxa-9b-aza-cyclopenta[a]naphthalene (896462-42-3) + (S)-(1-(2-bromophenyl)pyrrolidin-2-yl)methanol (896462-37-6)

Guidance literature:

With sodium hydroxide; copper(l) iodide; In isopropyl alcohol; at 90 ℃; for 24h;

DOI:10.1016/j.tetlet.2007.01.057

Reference yield: 30.0%

((S)-1-phenylpyrrolidin-2-yl)methanol (896462-34-3) → (3aS)-2,3,3a,4-tetrahydro-1H-5-oxa-9b-aza-cyclopenta[a]naphthalene (896462-42-3) + (S)-(1-(4-bromophenyl)pyrrolidin-2-yl)methanol + (S)-(1-(2-bromophenyl)pyrrolidin-2-yl)methanol (896462-37-6)

Guidance literature:

((S)-1-phenylpyrrolidin-2-yl)methanol; With n-butyllithium; N,N,N,N,-tetramethylethylenediamine; In diethyl ether; Heating;

With bromine; In diethyl ether; at -78 ℃;

DOI:10.1016/j.tetasy.2006.03.010

Reference yield: 34.0%

(3aS)-2,3,3a,4-tetrahydro-1H-5-oxa-9b-aza-cyclopenta[a]naphthalene (896462-42-3) + chloro-diphenylphosphine (1079-66-9,74391-44-9) → H2C11H11NOC12H9P

Guidance literature:

(3aS)-2,3,3a,4-tetrahydro-1H-5-oxa-9b-aza-cyclopenta[a]naphthalene; With n-butyllithium; N,N,N,N,-tetramethylethylenediamine; In diethyl ether; at -78 ℃;

chloro-diphenylphosphine; In diethyl ether; at -78 - 0 ℃; Further stages.;

DOI:10.1016/j.tetlet.2007.01.057

upstream raw materials:

((S)-1-phenylpyrrolidin-2-yl)methanol

1-Bromo-2-iodobenzene

(S)-1-Pyrrolidin-2-yl-methanol