3-ferrocenyl-1-(p-tolyl)prop-2-yn-1-one

Base Information

• Chemical Name: 3-ferrocenyl-1-(p-tolyl)prop-2-yn-1-one
• CAS No.: 912552-78-4
• Molecular Formula: C₂₀H₁₆FeO
• Molecular Weight: 328.193
• Mol file: 912552-78-4.mol

Synonyms:3-ferrocenyl-1-(p-tolyl)prop-2-yn-1-one

Chemical Property of 3-ferrocenyl-1-(p-tolyl)prop-2-yn-1-one

Chemical Property:

Purity/Quality:

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Technology Process of 3-ferrocenyl-1-(p-tolyl)prop-2-yn-1-one

There total 1 articles about 3-ferrocenyl-1-(p-tolyl)prop-2-yn-1-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

ferroceneacetylene (1271-47-2) + 4-methyl-benzoyl chloride (874-60-2) → 3-ferrocenyl-1-(p-tolyl)prop-2-yn-1-one (912552-78-4)

Guidance literature:

4-methyl-benzoyl chloride; With bis-triphenylphosphine-palladium(II) chloride; triethylamine; In tetrahydrofuran; at 20 ℃; for 0.166667h; Inert atmosphere;

With copper(l) iodide; In tetrahydrofuran; at 20 ℃; for 0.166667h; Inert atmosphere;

ferroceneacetylene; In tetrahydrofuran; at 20 ℃; for 6.25h; Inert atmosphere;

DOI:10.1016/j.tetlet.2016.09.080

Reference yield: 80.0%

6-Amino-1,3-dimethylbarbituric acid (6642-31-5) + 3-ferrocenyl-1-(p-tolyl)prop-2-yn-1-one (912552-78-4) → 1-m-methylphenyl-3-methylamino-3-ferrocenyl-2-propenone (1198428-15-7)

Guidance literature:

With CO; KCN; nickel(II) cyanide tetrahydrate; In sodium hydroxide; aq. NaOH; 5 N NaOH saturated with CO at room temp. for 30 min, Ni-compd. added, stirred under CO atmosphere, KCN added, uracil-compd. and Fe-compd. added at 55°C, stirred for 15 min; crystallized;

DOI:10.1016/j.jorganchem.2009.07.017

Reference yield: 69.0%

3-ferrocenyl-1-(p-tolyl)prop-2-yn-1-one (912552-78-4) + Propargylamine (2450-71-7) → (2-ferrocenylpyridin-3-yl)(p-tolyl)methanone

Guidance literature:

With copper(l) chloride; In N,N-dimethyl-formamide; at 110 ℃; for 2h; under 760.051 Torr;

DOI:10.1016/j.tetlet.2016.09.080

upstream raw materials:

ferroceneacetylene

4-methyl-benzoyl chloride

Downstream raw materials:

1-m-methylphenyl-3-methylamino-3-ferrocenyl-2-propenone

8-ferrocenyl-4-methyl-6-p-tolyl-2H-pyrano[3,2-g]quinolin-2-one

7-(1-ferrocenyl-3-(p-tolyl)-3-oxoprop-1-enylamino)-4-methyl-2H-chromen-2-one