(3R,4S,5S,6R)-2-(4-chloro-3-((4-(methoxy-d3)phenyl)methyl-d2)phenyl)-6-(hydroxymethyl)-2-methoxytetrahydro-2H-pyran-3,4,5-triol

Base Information

Chemical Name:(3R,4S,5S,6R)-2-(4-chloro-3-((4-(methoxy-d3)phenyl)methyl-d2)phenyl)-6-(hydroxymethyl)-2-methoxytetrahydro-2H-pyran-3,4,5-triol
CAS No.:1204219-55-5
Molecular Formula:C₂₁H₂₅ClO₇
Molecular Weight:429.839
Hs Code.:

Synonyms:(3R,4S,5S,6R)-2-(4-chloro-3-((4-(methoxy-d3)phenyl)methyl-d2)phenyl)-6-(hydroxymethyl)-2-methoxytetrahydro-2H-pyran-3,4,5-triol

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Chemical Property of (3R,4S,5S,6R)-2-(4-chloro-3-((4-(methoxy-d3)phenyl)methyl-d2)phenyl)-6-(hydroxymethyl)-2-methoxytetrahydro-2H-pyran-3,4,5-triol

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Technology Process of (3R,4S,5S,6R)-2-(4-chloro-3-((4-(methoxy-d3)phenyl)methyl-d2)phenyl)-6-(hydroxymethyl)-2-methoxytetrahydro-2H-pyran-3,4,5-triol

There total 8 articles about (3R,4S,5S,6R)-2-(4-chloro-3-((4-(methoxy-d3)phenyl)methyl-d2)phenyl)-6-(hydroxymethyl)-2-methoxytetrahydro-2H-pyran-3,4,5-triol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 461432-22-4
(5-bromo-2-chlorophenyl)(4-ethyloxyphenyl)methanone

: 1204219-55-5
(3R,4S,5S,6R)-2-(4-chloro-3-((4-(methoxy-d3)phenyl)methyl-d2)phenyl)-6-(hydroxymethyl)-2-methoxytetrahydro-2H-pyran-3,4,5-triol

Guidance literature:: Multi-step reaction with 4 steps

1.1: aluminum (III) chloride; sodium borodeuteride / tetrahydrofuran / 5 - 70 °C

2.1: boron tribromide / dichloromethane / -60 - 25 °C

2.2: Cooling with ice

3.1: potassium carbonate / acetone / 20 - 75 °C

4.1: n-butyllithium / tetrahydrofuran; hexane; toluene / -78 - -70 °C

4.2: 5 h / -78 - -70 °C

4.3: 20 °C

With aluminum (III) chloride; n-butyllithium; sodium borodeuteride; boron tribromide; potassium carbonate; In tetrahydrofuran; hexane; dichloromethane; acetone; toluene;

Reference yield:

: 67-56-1
methanol

: 1204219-53-3
4-bromo-1-chloro-2-((4-(methoxy-d3)phenyl)methyl-d2)benzene

: 32469-28-6,55515-28-1,55515-29-2,32384-65-9
(3R,4S,5R,6R)-3,4,5-tris((trimethylsilyl)oxy)-6-(((trimethylsilyl)oxy)methyl)tetrahydro-2H-pyran-2-one

: 1204219-55-5
(3R,4S,5S,6R)-2-(4-chloro-3-((4-(methoxy-d3)phenyl)methyl-d2)phenyl)-6-(hydroxymethyl)-2-methoxytetrahydro-2H-pyran-3,4,5-triol

Guidance literature:: 4-bromo-1-chloro-2-((4-(methoxy-d3)phenyl)methyl-d2)benzene; With n-butyllithium; In tetrahydrofuran; hexane; toluene; at -78 - -70 ℃;

(3R,4S,5R,6R)-3,4,5-tris((trimethylsilyl)oxy)-6-(((trimethylsilyl)oxy)methyl)tetrahydro-2H-pyran-2-one; In tetrahydrofuran; hexane; toluene; at -78 - -70 ℃; for 5h;

methanol; With methanesulfonic acid; In tetrahydrofuran; hexane; toluene; at 20 ℃; Product distribution / selectivity;

Reference yield:

: 21739-92-4
5-bromo-2-chlorobenzoic acid

: 1204219-55-5
(3R,4S,5S,6R)-2-(4-chloro-3-((4-(methoxy-d3)phenyl)methyl-d2)phenyl)-6-(hydroxymethyl)-2-methoxytetrahydro-2H-pyran-3,4,5-triol

Guidance literature:: Multi-step reaction with 6 steps

1.1: oxalyl dichloride; N,N-dimethyl-formamide / dichloromethane / 10 h / 20 °C / Industry scale

2.1: aluminum (III) chloride / dichloromethane / -3 - 4 °C / Industry scale

3.1: aluminum (III) chloride; sodium borodeuteride / tetrahydrofuran / 5 - 70 °C

4.1: boron tribromide / dichloromethane / -60 - 25 °C

4.2: Cooling with ice

5.1: potassium carbonate / acetone / 20 - 75 °C

6.1: n-butyllithium / tetrahydrofuran; hexane; toluene / -78 - -70 °C

6.2: 5 h / -78 - -70 °C

6.3: 20 °C

With aluminum (III) chloride; n-butyllithium; sodium borodeuteride; oxalyl dichloride; boron tribromide; potassium carbonate; N,N-dimethyl-formamide; In tetrahydrofuran; hexane; dichloromethane; acetone; toluene;