(1′S,2′R,3′R,4′R)-1′-[(N-3-methoxy-2-methylacryoyl)ureido]-2′-methoxy-1′-phenyl-3′,5′-O-tetraisopropyldisiloxy-ribose

Base Information

Chemical Name:(1′S,2′R,3′R,4′R)-1′-[(N-3-methoxy-2-methylacryoyl)ureido]-2′-methoxy-1′-phenyl-3′,5′-O-tetraisopropyldisiloxy-ribose
CAS No.:1418182-81-6
Molecular Formula:C₃₂H₅₄N₂O₈Si₂
Molecular Weight:650.96
Hs Code.:

Synonyms:(1′S,2′R,3′R,4′R)-1′-[(N-3-methoxy-2-methylacryoyl)ureido]-2′-methoxy-1′-phenyl-3′,5′-O-tetraisopropyldisiloxy-ribose

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Chemical Property of (1′S,2′R,3′R,4′R)-1′-[(N-3-methoxy-2-methylacryoyl)ureido]-2′-methoxy-1′-phenyl-3′,5′-O-tetraisopropyldisiloxy-ribose

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Technology Process of (1′S,2′R,3′R,4′R)-1′-[(N-3-methoxy-2-methylacryoyl)ureido]-2′-methoxy-1′-phenyl-3′,5′-O-tetraisopropyldisiloxy-ribose

There total 8 articles about (1′S,2′R,3′R,4′R)-1′-[(N-3-methoxy-2-methylacryoyl)ureido]-2′-methoxy-1′-phenyl-3′,5′-O-tetraisopropyldisiloxy-ribose which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 1418182-79-2
(1′S,2′R,3′R,4′R)-1′-(2-aminoethyl)-2′-methoxy-1′-phenyl-3′,5′-O-tetraisopropyldisiloxyribose

: 77268-18-9
β-methoxy-α-methylacryloyl isocyanate

: 1418182-81-6
(1′S,2′R,3′R,4′R)-1′-[(N-3-methoxy-2-methylacryoyl)ureido]-2′-methoxy-1′-phenyl-3′,5′-O-tetraisopropyldisiloxy-ribose

Guidance literature:: In benzene; for 5h;
DOI:10.1016/j.tet.2012.11.016

Reference yield:

: 1418182-78-1
(1′S,2′R,3′R,4′R)-1′-(2-formylethyl)-2′-methoxy-1′-phenyl-3′,5′-O-tetraisopropyldisiloxyribose

: 1418182-81-6
(1′S,2′R,3′R,4′R)-1′-[(N-3-methoxy-2-methylacryoyl)ureido]-2′-methoxy-1′-phenyl-3′,5′-O-tetraisopropyldisiloxy-ribose

Guidance literature:: Multi-step reaction with 3 steps

1: pyridine; hydroxylamine hydrochloride / ethanol / 16 h / 70 °C

2: nickel dichloride; sodium tetrahydroborate / methanol / 2 h / -78 °C

3: benzene / 5 h

With pyridine; sodium tetrahydroborate; hydroxylamine hydrochloride; nickel dichloride; In methanol; ethanol; benzene;
DOI:10.1016/j.tet.2012.11.016

Reference yield:

: 1418182-77-0
(1′S,2′R,3′R,4′R)-1′-allyl-2′-methoxy-1′-phenyl-3′,5′-O-tetraisopropyldisiloxyribose

: 1418182-81-6
(1′S,2′R,3′R,4′R)-1′-[(N-3-methoxy-2-methylacryoyl)ureido]-2′-methoxy-1′-phenyl-3′,5′-O-tetraisopropyldisiloxy-ribose

Guidance literature:: Multi-step reaction with 4 steps

1: pyridine; osmium(VIII) oxide; sodium periodate / water / 3 h

2: pyridine; hydroxylamine hydrochloride / ethanol / 16 h / 70 °C

3: nickel dichloride; sodium tetrahydroborate / methanol / 2 h / -78 °C

4: benzene / 5 h

With pyridine; sodium tetrahydroborate; sodium periodate; osmium(VIII) oxide; hydroxylamine hydrochloride; nickel dichloride; In methanol; ethanol; water; benzene;
DOI:10.1016/j.tet.2012.11.016