4-METHYLAMINO-BENZAMIDE

Base Information

• Chemical Name: 4-METHYLAMINO-BENZAMIDE
• CAS No.: 38359-26-1
• Molecular Formula: C8H10 N2 O
• Molecular Weight: 150.18
• Hs Code.: 2924299090
• Mol file: 38359-26-1.mol

Synonyms:4-Aminomethylbenzoicacid amide

Chemical Property of 4-METHYLAMINO-BENZAMIDE

Chemical Property:

• Vapor Pressure: 0.000158mmHg at 25°C
• Refractive Index: 1.619
• Boiling Point: 331.2°C at 760 mmHg
• Flash Point: 154.1°C
• PSA: 55.12000
• Density: 1.177g/cm³
• LogP: 1.60050

Purity/Quality:

98% ^*data from raw suppliers

4-(METHYLAMINO)BENZAMIDE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4-METHYLAMINO-BENZAMIDE

There total 11 articles about 4-METHYLAMINO-BENZAMIDE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

methanol (67-56-1) + 4-aminobenzamide (2835-68-9) → N-methyl-p-aminobenzamide (38359-26-1) + N-methyl-4-(methylamino)benzamide

Guidance literature:

With C₅₄H₄₃ClN₃P₂Ru⁽¹⁺⁾*F₆P^(1-); caesium carbonate; In toluene; at 140 ℃; for 12h; Inert atmosphere; Sealed tube; Green chemistry;

DOI:10.1021/acs.orglett.9b01925

Reference yield: 92.0%

methanol (67-56-1) + 4-aminobenzamide (2835-68-9) → N-methyl-p-aminobenzamide (38359-26-1)

Guidance literature:

With C₁₉H₂₄ClN₂Ru; sodium hydroxide; at 80 ℃; for 22h;

DOI:10.1039/d0cy02210a

Reference yield: 86.0%

4-aminobenzamide (2835-68-9) + carbonic acid dimethyl ester (616-38-6) → 4-(dimethylamino)benzamide (6083-47-2) + N-methyl-p-aminobenzamide (38359-26-1)

Guidance literature:

With sodium-exchanged Y-zeolite; at 90 ℃; for 24h;

DOI:10.1021/jo034548a

upstream raw materials:

4-aminobenzamide

carbonic acid dimethyl ester

2-(2-Methoxyethoxy)ethyl methyl carbonate

carbon monoxide

Refernces

• 1、 Sarki, Naina,Goyal, Vishakha,Tyagi, Nitin Kumar,Puttaswamy,Narani, Anand,Ray, Anjan,Natte, Kishore. "Simple RuCl3-catalyzed N-Methylation of Amines and Transfer Hydrogenation of Nitroarenes using Methanol". . p. 1722 - 1729. Retrieved 2021/04/19.
• 2、 Paul, Bhaskar,Maji, Milan,Panja, Dibyajyoti,Kundu, Sabuj. "Tandem Transformation of Aldoximes to N-Methylated Amides Using Methanol". supporting information. p. 5357 - 5362. Retrieved 2019/11/14.