(R)-4-[(S)-2-(tert-Butyl-diphenyl-silanyloxy)-1-triethylsilanyloxy-ethyl]-4-methylsulfanylmethoxy-octanoic acid methoxy-methyl-amide

Base Information

Chemical Name:(R)-4-[(S)-2-(tert-Butyl-diphenyl-silanyloxy)-1-triethylsilanyloxy-ethyl]-4-methylsulfanylmethoxy-octanoic acid methoxy-methyl-amide
CAS No.:1054709-81-7
Molecular Formula:C₃₆H₆₁NO₅SSi₂
Molecular Weight:676.121
Hs Code.:

Synonyms:(R)-4-[(S)-2-(tert-Butyl-diphenyl-silanyloxy)-1-triethylsilanyloxy-ethyl]-4-methylsulfanylmethoxy-octanoic acid methoxy-methyl-amide

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Chemical Property of (R)-4-[(S)-2-(tert-Butyl-diphenyl-silanyloxy)-1-triethylsilanyloxy-ethyl]-4-methylsulfanylmethoxy-octanoic acid methoxy-methyl-amide

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Technology Process of (R)-4-[(S)-2-(tert-Butyl-diphenyl-silanyloxy)-1-triethylsilanyloxy-ethyl]-4-methylsulfanylmethoxy-octanoic acid methoxy-methyl-amide

There total 6 articles about (R)-4-[(S)-2-(tert-Butyl-diphenyl-silanyloxy)-1-triethylsilanyloxy-ethyl]-4-methylsulfanylmethoxy-octanoic acid methoxy-methyl-amide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: (R)-5-Butyl-5-[(S)-2-(tert-butyl-diphenyl-silanyloxy)-1-triethylsilanyloxy-ethyl]-dihydro-furan-2-one

: 6638-79-5
N,O-dimethylhydroxylamine*hydrochloride

: 67-68-5,8070-53-9
dimethyl sulfoxide

: 1054709-81-7
(R)-4-[(S)-2-(tert-Butyl-diphenyl-silanyloxy)-1-triethylsilanyloxy-ethyl]-4-methylsulfanylmethoxy-octanoic acid methoxy-methyl-amide

Guidance literature:: (R)-5-Butyl-5-[(S)-2-(tert-butyl-diphenyl-silanyloxy)-1-triethylsilanyloxy-ethyl]-dihydro-furan-2-one; N,O-dimethylhydroxylamine*hydrochloride; With dimethylaluminum chloride; In dichloromethane; at 0 - 20 ℃;

With 1H-imidazole; dmap; triethylsilyl chloride; In N,N-dimethyl-formamide; at 0 - 20 ℃;

dimethyl sulfoxide; With acetic anhydride; at 20 ℃; Further stages.;
DOI:10.1021/ol0060634

Reference yield:

: (S)-2-(tert-Butyl-diphenyl-silanyloxy)-1-((R)-2-butyl-tetrahydro-furan-2-yl)-ethanol

: 1054709-81-7
(R)-4-[(S)-2-(tert-Butyl-diphenyl-silanyloxy)-1-triethylsilanyloxy-ethyl]-4-methylsulfanylmethoxy-octanoic acid methoxy-methyl-amide

Guidance literature:: Multi-step reaction with 3 steps

1.1: dimethylformamide / 0 - 20 °C

2.1: 20 percent / RuCl₃; NaIO₄ / acetonitrile; CCl₄; aq. phosphate buffer / 20 °C / pH 8

3.1: Me₂AlCl / CH₂Cl₂ / 0 - 20 °C

3.2: TESCl; imidazole; DMAP / dimethylformamide / 0 - 20 °C

3.3: Ac₂O / 20 °C

With ruthenium trichloride; sodium periodate; dimethylaluminum chloride; In tetrachloromethane; phosphate buffer; dichloromethane; N,N-dimethyl-formamide; acetonitrile; 1.1: Addition / 2.1: Substitution / 3.1: Addition / 3.2: Addition / 3.3: Addition;
DOI:10.1021/ol0060634

Reference yield:

: (R)-2-Butyl-2-[(S)-2-(tert-butyl-diphenyl-silanyloxy)-1-triethylsilanyloxy-ethyl]-tetrahydro-furan

: 1054709-81-7
(R)-4-[(S)-2-(tert-Butyl-diphenyl-silanyloxy)-1-triethylsilanyloxy-ethyl]-4-methylsulfanylmethoxy-octanoic acid methoxy-methyl-amide

Guidance literature:: Multi-step reaction with 2 steps

1.1: 20 percent / RuCl₃; NaIO₄ / acetonitrile; CCl₄; aq. phosphate buffer / 20 °C / pH 8

2.1: Me₂AlCl / CH₂Cl₂ / 0 - 20 °C

2.2: TESCl; imidazole; DMAP / dimethylformamide / 0 - 20 °C

2.3: Ac₂O / 20 °C

With ruthenium trichloride; sodium periodate; dimethylaluminum chloride; In tetrachloromethane; phosphate buffer; dichloromethane; acetonitrile; 1.1: Substitution / 2.1: Addition / 2.2: Addition / 2.3: Addition;
DOI:10.1021/ol0060634