4-[6-(5-methanesulfonyl-2,3-dihydro-indol-1-yl)-pyrimidin-4-yloxy]-piperidine-1-carboxylic acid 1-(2-fluoro-benzyl)-pyrrolidin-3-yl ester

Base Information

Chemical Name:4-[6-(5-methanesulfonyl-2,3-dihydro-indol-1-yl)-pyrimidin-4-yloxy]-piperidine-1-carboxylic acid 1-(2-fluoro-benzyl)-pyrrolidin-3-yl ester
CAS No.:1259510-62-7
Molecular Formula:C₃₀H₃₄FN₅O₅S
Molecular Weight:595.695
Hs Code.:

Synonyms:4-[6-(5-methanesulfonyl-2,3-dihydro-indol-1-yl)-pyrimidin-4-yloxy]-piperidine-1-carboxylic acid 1-(2-fluoro-benzyl)-pyrrolidin-3-yl ester

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Chemical Property of 4-[6-(5-methanesulfonyl-2,3-dihydro-indol-1-yl)-pyrimidin-4-yloxy]-piperidine-1-carboxylic acid 1-(2-fluoro-benzyl)-pyrrolidin-3-yl ester

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Technology Process of 4-[6-(5-methanesulfonyl-2,3-dihydro-indol-1-yl)-pyrimidin-4-yloxy]-piperidine-1-carboxylic acid 1-(2-fluoro-benzyl)-pyrrolidin-3-yl ester

There total 7 articles about 4-[6-(5-methanesulfonyl-2,3-dihydro-indol-1-yl)-pyrimidin-4-yloxy]-piperidine-1-carboxylic acid 1-(2-fluoro-benzyl)-pyrrolidin-3-yl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1259510-70-7
4-[6-(5-methanesulfonyl-2,3-dihydro-indol-1-yl)-pyrimidin-4-yloxy]-piperidine-1-carboxylic acid pyrrolidin-3-yl ester

: 446-52-6
2-Fluorobenzaldehyde

: 1259510-62-7
4-[6-(5-methanesulfonyl-2,3-dihydro-indol-1-yl)-pyrimidin-4-yloxy]-piperidine-1-carboxylic acid 1-(2-fluoro-benzyl)-pyrrolidin-3-yl ester

Guidance literature:: With sodium tris(acetoxy)borohydride; In 1,2-dichloro-ethane; at 20 ℃; for 8h;

Reference yield:

: 1259510-85-4
4-[6-(5-methanesulfonyl-2,3-dihydro-indol-1-yl)-pyrimidin-4-yloxy]-piperidine-1-carboxylic acid 1-benzyl-pyrrolidin-3-yl ester

: 1259510-62-7
4-[6-(5-methanesulfonyl-2,3-dihydro-indol-1-yl)-pyrimidin-4-yloxy]-piperidine-1-carboxylic acid 1-(2-fluoro-benzyl)-pyrrolidin-3-yl ester

Guidance literature:: Multi-step reaction with 2 steps

1: hydrogen / palladium on activated charcoal / ethanol / 12 h / 3102.97 Torr

2: sodium tris(acetoxy)borohydride / 1,2-dichloro-ethane / 8 h / 20 °C

With hydrogen; sodium tris(acetoxy)borohydride; palladium on activated charcoal; In ethanol; 1,2-dichloro-ethane;

Reference yield:

: 442199-19-1
tert-butyl 4-((6-chloropyrimidin-4-yl)oxy)piperidine-1-carboxylate

: 1259510-62-7
4-[6-(5-methanesulfonyl-2,3-dihydro-indol-1-yl)-pyrimidin-4-yloxy]-piperidine-1-carboxylic acid 1-(2-fluoro-benzyl)-pyrrolidin-3-yl ester

Guidance literature:: Multi-step reaction with 5 steps

1.1: sodium hydride / N,N-dimethyl-formamide / 0.17 h / 20 °C

1.2: 18 h / 80 °C

2.1: trifluoroacetic acid / dichloromethane / 3 h / 20 °C

3.1: triethylamine / dichloromethane / 12 h / 20 °C

3.2: 8 h / 20 °C

4.1: trifluoroacetic acid / dichloromethane / 2 h / 20 °C

5.1: sodium tris(acetoxy)borohydride / 1,2-dichloro-ethane / 8 h / 20 °C

With sodium tris(acetoxy)borohydride; sodium hydride; triethylamine; trifluoroacetic acid; In dichloromethane; 1,2-dichloro-ethane; N,N-dimethyl-formamide;