4-(6-Chloro-pyriMidin-4-yloxy)-piperidine-1-carboxylic acid tert-butyl ester, 98+% C14H20ClN3O3, MW: 313.78

Base Information

• Chemical Name: 4-(6-Chloro-pyriMidin-4-yloxy)-piperidine-1-carboxylic acid tert-butyl ester, 98+% C14H20ClN3O3, MW: 313.78
• CAS No.: 442199-19-1
• Molecular Formula: C14H20ClN3O3
• Molecular Weight: 313.784
• Hs Code.: 2933990090
• Mol file: 442199-19-1.mol

Synonyms:tert-butyl 4-[(6-chloro-4-pyrimidinyl)oxy]-1-piperidinecarboxylate;tert-butyl 4-(6-chloropyrimidin-4-yloxy)piperidine-1-carboxylate;tert-butyl 4-(6-chloropyrimidin-4-yloxy)piperidinecarboxylate;4-(6-chloro-pyrimidin-4-yloxy)-piperidine-1-carboxylic acid tert-butyl ester;QC-5636;

Chemical Property of 4-(6-Chloro-pyriMidin-4-yloxy)-piperidine-1-carboxylic acid tert-butyl ester, 98+% C14H20ClN3O3, MW: 313.78

Chemical Property:

• PSA: 64.55000
• Density: 1.242
• LogP: 2.84620
• Storage Temp.: 2-8°C

Purity/Quality:

99%+, ^*data from raw suppliers

tert-Butyl4-((6-chloropyrimidin-4-yl)oxy)piperidine-1-carboxylate 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4-(6-Chloro-pyriMidin-4-yloxy)-piperidine-1-carboxylic acid tert-butyl ester, 98+% C14H20ClN3O3, MW: 313.78

There total 4 articles about 4-(6-Chloro-pyriMidin-4-yloxy)-piperidine-1-carboxylic acid tert-butyl ester, 98+% C14H20ClN3O3, MW: 313.78 which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

4,6-dichloropyrimidine (1193-21-1) + t-butyl 4-hydroxy piperidine-1-carboxylate (109384-19-2) → tert-butyl 4-((6-chloropyrimidin-4-yl)oxy)piperidine-1-carboxylate (442199-19-1)

Guidance literature:

t-butyl 4-hydroxy piperidine-1-carboxylate; With sodium hydride; In tetrahydrofuran; mineral oil; at 60 ℃; for 1h;

4,6-dichloropyrimidine; In tetrahydrofuran; mineral oil; at 20 ℃; for 2h;

Reference yield: 66.0%

→ tert-butyl 4-((6-chloropyrimidin-4-yl)oxy)piperidine-1-carboxylate (442199-19-1)

Guidance literature:

Reference yield: 29.0%

4,6-dichloropyrimidine (1193-21-1) → tert-butyl 4-((6-chloropyrimidin-4-yl)oxy)piperidine-1-carboxylate (442199-19-1)

Guidance literature:

t-butyl 4-hydroxy piperidine-1-carboxylate; With sodium hydride; In tetrahydrofuran; at 60 ℃; for 0.666667h;

4,6-dichloropyrimidine; In tetrahydrofuran; at 20 ℃; for 0.333333h;

With water; In tetrahydrofuran;

upstream raw materials:

4,6-dichloropyrimidine

t-butyl 4-hydroxy piperidine-1-carboxylate

Downstream raw materials:

C₂₃H₂₉FN₄O₅S

C₂₃H₂₈FN₃O₆S

4-chloro-6-(piperidin-4-yloxy)pyrimidine dihydrochloride

tert-butyl 4-(6-aminopyrimidin-4-yloxy)piperidine-1-carboxylate

Refernces

• 1、 -. "TETRAHYDROISOQUINOLINE DERIVED PRMT5-INHIBITORS". Page/Page column 105-106. . Retrieved 2016/03/19.
• 2、 -. "2, 7 -NAPHTHYRIDIN- 1 -ONE DERIVATIVES AS SYK KINASE INHIBITORS". Page/Page column 118. . Retrieved 2011/02/24.