{1-[5-oxo-4-(4-pyridin-2-ylbenzyl)tetrahydrofuran-2-yl]-2-phenylethyl}carbamic acid tert-butyl ester

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Chemical Name:{1-[5-oxo-4-(4-pyridin-2-ylbenzyl)tetrahydrofuran-2-yl]-2-phenylethyl}carbamic acid tert-butyl ester
CAS No.:854753-93-8
Molecular Formula:C₂₉H₃₂N₂O₄
Molecular Weight:472.584
Hs Code.:

Synonyms:{1-[5-oxo-4-(4-pyridin-2-ylbenzyl)tetrahydrofuran-2-yl]-2-phenylethyl}carbamic acid tert-butyl ester

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Chemical Property of {1-[5-oxo-4-(4-pyridin-2-ylbenzyl)tetrahydrofuran-2-yl]-2-phenylethyl}carbamic acid tert-butyl ester

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Technology Process of {1-[5-oxo-4-(4-pyridin-2-ylbenzyl)tetrahydrofuran-2-yl]-2-phenylethyl}carbamic acid tert-butyl ester

There total 1 articles about {1-[5-oxo-4-(4-pyridin-2-ylbenzyl)tetrahydrofuran-2-yl]-2-phenylethyl}carbamic acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 98760-08-8
(2R,3S)-3-[N-(tert-butyloxycarbonyl)amino]-1,2-epoxy-4-phenylbutane

: 52199-24-3
2-[(4-bromomethyl)phenyl]pyridine

: 105-53-3
diethyl malonate

: 854753-93-8
{1-[5-oxo-4-(4-pyridin-2-ylbenzyl)tetrahydrofuran-2-yl]-2-phenylethyl}carbamic acid tert-butyl ester

Guidance literature:: (2R,3S)-3-[N-(tert-butyloxycarbonyl)amino]-1,2-epoxy-4-phenylbutane; diethyl malonate; With sodium ethanolate; In ethanol; at 0 - 25 ℃; for 3.16667h;

2-[(4-bromomethyl)phenyl]pyridine; In ethanol; at 0 - 25 ℃; for 16h;

With hydrogenchloride; lithium hydroxide; water; more than 3 stages;

Reference yield: 49.0%

: 854753-93-8
{1-[5-oxo-4-(4-pyridin-2-ylbenzyl)tetrahydrofuran-2-yl]-2-phenylethyl}carbamic acid tert-butyl ester

: 18162-48-6
tert-butyldimethylsilyl chloride

: 854753-94-9
(4S,5S)-5-(tert-butoxycarbonylamino)-4-(tert-butyldimethylsilyloxy)-6-phenyl-2-(4-(pyridin-2-yl)benzyl)hexanoic acid

Guidance literature:: {1-[5-oxo-4-(4-pyridin-2-ylbenzyl)tetrahydrofuran-2-yl]-2-phenylethyl}carbamic acid tert-butyl ester; With sodium hydroxide; water; In 1,4-dioxane; at 25 ℃; for 0.5h;

With hydrogenchloride; In water; at 0 ℃; pH=5;

tert-butyldimethylsilyl chloride; With 1H-imidazole; hydrogenchloride; more than 3 stages;

Reference yield:

: 854753-93-8
{1-[5-oxo-4-(4-pyridin-2-ylbenzyl)tetrahydrofuran-2-yl]-2-phenylethyl}carbamic acid tert-butyl ester

: C₂₉H₃₄N₂O₅

Guidance literature:: {1-[5-oxo-4-(4-pyridin-2-ylbenzyl)tetrahydrofuran-2-yl]-2-phenylethyl}carbamic acid tert-butyl ester; With sodium hydroxide; In 1,4-dioxane; at 20 ℃; for 0.5h;

With hydrogenchloride; In water; at 0 ℃; pH=5;
DOI:10.1021/jm900044w