3-(4-bromo-3-ethyl-2-hydroxyphenyl)-1,2-epoxypropane

Base Information

Chemical Name:3-(4-bromo-3-ethyl-2-hydroxyphenyl)-1,2-epoxypropane
CAS No.:137206-67-8
Molecular Formula:C₁₁H₁₃BrO₂
Molecular Weight:257.127
Hs Code.:

Synonyms:3-(4-bromo-3-ethyl-2-hydroxyphenyl)-1,2-epoxypropane

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Chemical Property of 3-(4-bromo-3-ethyl-2-hydroxyphenyl)-1,2-epoxypropane

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Technology Process of 3-(4-bromo-3-ethyl-2-hydroxyphenyl)-1,2-epoxypropane

There total 2 articles about 3-(4-bromo-3-ethyl-2-hydroxyphenyl)-1,2-epoxypropane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 18980-21-7
4-bromo-2-ethylphenol

: 137206-67-8
3-(4-bromo-3-ethyl-2-hydroxyphenyl)-1,2-epoxypropane

Guidance literature:: Multi-step reaction with 3 steps

1: 1) potassium tert-butoxide / 1) tert-butyl alcohol, reflux, o.5 h, 2) tert-butyl alcohol, reflux, 8 h

2: 82 percent / N,N-dimethylaniline / 2.5 h / 193 °C

3: 84 percent / m-chloroperbenzoic acid / CH₂Cl₂ / 0 deg C to 22 deg C, 22 h

With potassium tert-butylate; N,N-dimethyl-aniline; 3-chloro-benzenecarboperoxoic acid; In dichloromethane;
DOI:10.1002/jhet.5570280535

Reference yield:

: 137206-65-6
4-bromo-2-ethylphenyl allyl ether

: 137206-67-8
3-(4-bromo-3-ethyl-2-hydroxyphenyl)-1,2-epoxypropane

Guidance literature:: Multi-step reaction with 2 steps

1: 82 percent / N,N-dimethylaniline / 2.5 h / 193 °C

2: 84 percent / m-chloroperbenzoic acid / CH₂Cl₂ / 0 deg C to 22 deg C, 22 h

With N,N-dimethyl-aniline; 3-chloro-benzenecarboperoxoic acid; In dichloromethane;
DOI:10.1002/jhet.5570280535

Reference yield:

: 137206-67-8
3-(4-bromo-3-ethyl-2-hydroxyphenyl)-1,2-epoxypropane

: 60398-91-6
Bufuralol hydrochloride

Guidance literature:: Multi-step reaction with 10 steps

1: 75 percent / potassium hydroxide, water / dimethylsulfoxide / 3 h / 23 °C

2: 96 percent / triethylamine, 4-dimethylaminopyridine / CH₂Cl₂ / 8 h / 22 °C

3: 91 percent / N-bromosuccinimide, benzoylperoxide / CCl₄ / Heating; Irradiation

4: sodium cyanoborohydride, hexamethylphosphoramide / 10 h / 70 °C

5: 93 percent / potassium carbonate / methanol / 2 h / 22 °C

6: 81 percent / 2 M oxalyl chloride, dimethyl sulfoxide, triethylamine / CH₂Cl₂ / -60 °C

7: 1) sodium methylsulfinylmethide / 1) dimethyl sulfoxide, tetrahydrofuran, 0 deg C, 2 min, 2) tetrahydrofuran, 0 deg C, 30 min, then 24 deg C, 1 h

8: hexane; methanol / 14 h / Heating

9: hydrochloric acid / ethanol

10: 93 percent / hydrogen / 5 percent palladium on carbon / ethanol / 0.25 h / 775.7 Torr

With hydrogenchloride; N,N,N,N,N,N-hexamethylphosphoric triamide; dmap; potassium hydroxide; N-Bromosuccinimide; Perbenzoic acid; oxalyl dichloride; dimsylsodium; water; hydrogen; sodium cyanoborohydride; potassium carbonate; dimethyl sulfoxide; triethylamine; palladium on activated charcoal; In methanol; tetrachloromethane; ethanol; hexane; dichloromethane; dimethyl sulfoxide;
DOI:10.1002/jhet.5570280535